| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Licoflavone C targets multiple cellular pathways. It has been shown to induce estrogen receptor-dependent gene expression. Its antioxidant activity is likely mediated through its ability to scavenge free radicals and protect against oxidative stress. Its antimutagenic effects are demonstrated by its protective effect against chromosome damage induced by daunorubicin (DAU) or mitomycin C (MMC) in cultured human peripheral lymphocytes.
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| ln Vitro |
In vitro, licoflavone C has demonstrated potent antimutagenic effects. It protects against chromosome damage induced by daunorubicin (DAU) or mitomycin C (MMC) in cultured human peripheral lymphocytes. It also exhibits cytotoxic, antioxidative, and anti-inflammatory effects. These in vitro activities confirm its potential as a chemoprotective agent.
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| ln Vivo |
Detailed in vivo activity data for licoflavone C are not extensively provided in the search results. However, its antimutagenic and antioxidant properties suggest potential for in vivo efficacy in protecting against chemotherapy-induced side effects and other forms of oxidative stress. Its presence in licorice and other medicinal plants also hints at its traditional use.
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| Enzyme Assay |
Non-cell-based assays for licoflavone C would typically involve measuring its antioxidant activity in cell-free systems using assays such as DPPH radical scavenging or FRAP (ferric reducing antioxidant power). Its ability to bind to estrogen receptors could be measured using a radioligand binding assay.
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| Cell Assay |
Cellular assays for licoflavone C are performed using human peripheral lymphocytes. The cells are treated with a cancer drug (e.g., daunorubicin or mitomycin C) to induce chromosome damage, in the presence or absence of licoflavone C. The extent of chromosome damage is assessed by scoring micronuclei or chromosomal aberrations. The compound's protective effect is quantified as a reduction in damage compared to control.
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| Animal Protocol |
In vivo animal models for licoflavone C would likely involve the use of mice treated with a chemotherapeutic agent to induce genotoxicity. The compound would be administered, and its protective effect against DNA damage and other side effects would be assessed. These studies are crucial for evaluating the compound's potential as a chemoprotective agent. Detailed protocols are not provided in the search results.
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| ADME/Pharmacokinetics |
Licoflavone C has a molecular weight of 338.4 g/mol and a molecular formula of C20H18O5. It is a flavonoid that is soluble in DMSO. It has a purity of ≥98%. Detailed PK parameters such as half-life and bioavailability are not extensively detailed in the provided search results.
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| Toxicity/Toxicokinetics |
Detailed toxicological data for licoflavone C are not provided in the search results. As a natural product, it is generally considered to have a good safety profile, but thorough toxicological studies would be required for therapeutic development. The compound is intended for research use only and is not for human consumption.
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| References | |
| Additional Infomation |
According to reports, jackfruit, broom flowers, and other organisms with relevant data contain Licoagrochalcone C. See also: Licorice root (partial).
Licoflavone C is a prenylated flavone found in licorice and other plants. It has antioxidant, anti-inflammatory, anticancer, and antimutagenic activities. It protects against chromosome damage induced by cancer drugs. It has the CAS number 72357-31-4 and is supplied for research purposes. |
| Molecular Formula |
C20H18O5
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|---|---|
| Molecular Weight |
338.35
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| Exact Mass |
338.115
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| Elemental Analysis |
C, 71.00; H, 5.36; O, 23.64
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| CAS # |
72357-31-4
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| PubChem CID |
10246505
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| Appearance |
Light yellow to brown solid powder
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| LogP |
4.085
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
25
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| Complexity |
554
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C(C2C([H])=C([H])C(=C([H])C=2[H])O[H])=C([H])C(C2=C(C([H])=C(C(C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])=C12)O[H])O[H])=O
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| InChi Key |
CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C=C(O2)C3=CC=C(C=C3)O)C
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| InChi Code |
InChI=1S/C20H18O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9-10,21-23H,8H2,1-2H3
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| Chemical Name |
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one
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| Synonyms |
8-Prenylapigenin; Licoflavone C
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9555 mL | 14.7776 mL | 29.5552 mL | |
| 5 mM | 0.5911 mL | 2.9555 mL | 5.9110 mL | |
| 10 mM | 0.2956 mL | 1.4778 mL | 2.9555 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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