| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
The primary target of Lenacil is the photosynthetic apparatus in plants. Its mechanism of action involves the inhibition of photosynthesis, which leads to the death of weeds. By blocking the photosynthetic electron transport chain, Lenacil prevents the production of energy and essential metabolites required for plant growth.
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| ln Vitro |
In vitro, Lenacil is a herbicide that inhibits photosynthesis in susceptible plants. Its activity is assessed in plant-based assays measuring the inhibition of photosynthetic oxygen evolution or electron transport. The compound's selectivity for broadleaf weeds over crops is determined by comparing its effects on different plant species.
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| ln Vivo |
In vivo, Lenacil is used in agricultural settings to control the growth of broadleaf weeds. It is applied preplanting by soil incorporation or as a preemergence treatment. Its effectiveness in controlling weeds in crops such as sugar beets, strawberries, and ornamentals has been demonstrated in field studies.
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| Enzyme Assay |
In vitro enzyme/receptor binding studies are not applicable for Lenacil, as it is a herbicide that acts on the photosynthetic apparatus in plants. Its activity is assessed in plant-based assays measuring the inhibition of photosynthetic electron transport or oxygen evolution.
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| Cell Assay |
In vitro plant-based assays for Lenacil evaluate its herbicidal activity. Plants are grown in the presence of the compound, and the inhibition of growth or photosynthetic activity is measured. The compound's selectivity is assessed by testing against a range of weed and crop species.
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| Animal Protocol |
In vivo field studies for Lenacil are conducted to evaluate its herbicidal efficacy and crop safety. The compound is applied to fields at various rates, and the control of weed populations is assessed. Crop yield and phytotoxicity are also monitored to determine the safety of the compound for the target crop.
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| ADME/Pharmacokinetics |
The physicochemical properties of Lenacil include a density of 1.32 kg/L at 20°C. Its molecular weight is 234.29 g/mol. For agricultural use, it is formulated as a wettable powder or liquid concentrate. Further details on its environmental fate and behavior are available from the primary research literature.
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| Toxicity/Toxicokinetics |
The toxicity profile of Lenacil is classified as low toxicity. The oral LD₅₀ in rats is 11000 mg/kg. It is considered safe for use in agriculture when applied according to label instructions. However, as with all pesticides, it should be handled with care to avoid exposure.
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| References |
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| Additional Infomation |
Lenacil is a cyclopentanopyrimidine, specifically 6,7-dihydro-1H-cyclopentano[d]pyrimidine-2,4(3H,5H)-dione, substituted at the 3-position with a cyclohexyl group. It is an environmental pollutant, exogenous substance, herbicide, and agrochemical.
Additional information: Lenacil is a triazinone herbicide used for selective weed control in various crops. It acts by inhibiting photosynthesis. The compound is used preplanting by soil incorporation or as a preemergence treatment. This product is for research use only and is not intended for human consumption. |
| Molecular Formula |
C13H18N2O2
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|---|---|
| Molecular Weight |
234.3
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| Exact Mass |
234.137
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| CAS # |
2164-08-1
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| PubChem CID |
16559
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| Appearance |
White to off-white solid powder
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| Density |
1.32
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| Boiling Point |
411ºC at 760mmHg
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| Melting Point |
316-326°C
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| Flash Point |
202.4ºC
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| Vapour Pressure |
1.79E-08mmHg at 25°C
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| Index of Refraction |
1.584
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| LogP |
1.53
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
17
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| Complexity |
394
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZTMKADLOSYKWCA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H18N2O2/c16-12-10-7-4-8-11(10)14-13(17)15(12)9-5-2-1-3-6-9/h9H,1-8H2,(H,14,17)
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| Chemical Name |
1H-Cyclopentapyrimidine-2,4(3H,5H)-dione, 6,7-dihydro-3-cyclohexyl-
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| Synonyms |
Herbicide 634 Hexilure Lenacil
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2680 mL | 21.3402 mL | 42.6803 mL | |
| 5 mM | 0.8536 mL | 4.2680 mL | 8.5361 mL | |
| 10 mM | 0.4268 mL | 2.1340 mL | 4.2680 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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