| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Lauroyl alanine does not have a specific biological target. Its mechanism of action is physicochemical. As a surfactant, it reduces the surface tension of water, enabling the emulsification and removal of oils and dirt. Its mildness is attributed to its low irritation potential compared to other anionic surfactants. It is considered a biodegradable and skin-friendly ingredient.
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|---|---|
| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
In vitro, Lauroyl alanine is evaluated for its surfactant properties, such as surface tension reduction, foaming power, and emulsification capacity. Its mildness is assessed in cell culture models by measuring its cytotoxicity and irritation potential on skin cells. |
| ln Vivo |
In vivo, Lauroyl alanine is used as an ingredient in topical formulations. Its primary function is to cleanse the skin and hair and provide conditioning effects. It is not systemically absorbed and does not exert pharmacological effects.
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| Enzyme Assay |
Non-cell-based assays for Lauroyl alanine include measuring its physicochemical properties, such as surface tension, foaming power, and critical micelle concentration (CMC).
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| Cell Assay |
Cellular assays for Lauroyl alanine are performed using skin cell lines to assess its irritation potential. Cells are treated with the surfactant, and cell viability and the release of inflammatory mediators are measured.
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| Animal Protocol |
In vivo animal models for Lauroyl alanine are not commonly used, as it is a cosmetic ingredient. Its safety is assessed in human patch tests and clinical studies.
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| ADME/Pharmacokinetics |
Lauroyl alanine has a molecular weight of 271.40 g/mol and a molecular formula of C₁₅H₂₉NO₃. Its CAS number is 52558-74-4. The compound is a solid. Purity is typically ≥98%. Storage conditions: room temperature. The compound is supplied for research use only.
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| Toxicity/Toxicokinetics |
Lauroyl alanine is considered a safe and mild surfactant. The compound is intended for research use only in the context of this request and is not for human consumption. Standard laboratory safety precautions should be followed.
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| References |
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1039.
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| Additional Infomation |
Lauroyl alanine is a mild anionic surfactant used in personal care products. It is derived from L-alanine and lauric acid. Its CAS number is 52558-74-4.
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| Molecular Formula |
C15H29NO3
|
|---|---|
| Molecular Weight |
271.4
|
| Exact Mass |
271.215
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| CAS # |
52558-74-4
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| PubChem CID |
13854541
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| Appearance |
White to off-white solid powder
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| Density |
0.979g/cm3
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| Boiling Point |
452.1ºC at 760mmHg
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| Melting Point |
83 °C
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| Flash Point |
227.2ºC
|
| LogP |
3.887
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
12
|
| Heavy Atom Count |
19
|
| Complexity |
254
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| Defined Atom Stereocenter Count |
1
|
| SMILES |
CCCCCCCCCCCC(N[C@H](C(O)=O)C)=O
|
| InChi Key |
UYTOHYBIBPDOKX-ZDUSSCGKSA-N
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| InChi Code |
InChI=1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16-13(2)15(18)19/h13H,3-12H2,1-2H3,(H,16,17)(H,18,19)/t13-/m0/s1
|
| Chemical Name |
(2S)-2-(dodecanoylamino)propanoic acid
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| Synonyms |
Aminiosurfact LA; Lauroylalanine; Lauroyl alanine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6846 mL | 18.4230 mL | 36.8460 mL | |
| 5 mM | 0.7369 mL | 3.6846 mL | 7.3692 mL | |
| 10 mM | 0.3685 mL | 1.8423 mL | 3.6846 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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