| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
The contractile response brought on by an electric field stimulation is inhibited by L-798106 (200 nM) [2]. Acetylcholine release triggered by electric field stimulation is inhibited by L-798106 (10 μM) [2].
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|---|---|
| ln Vivo |
In db/db mice, L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 weeks) reduces AT inflammation and systemic insulin resistance [3].
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| Cell Assay |
Cell viability assay [2]
Cell Types: Guinea pig vas deferens Tested Concentrations: 200 nM Incubation Duration: Experimental Results: Apparent pA2 is 7.48±0.25. Cell viability assay [2] Cell Types: Guinea pig tracheal smooth muscle Tested Concentrations: 10 μM Incubation Duration: Experimental Results: The inhibitory effects of all tested drugs were Dramatically attenuated (% inhibition of EFS-induced release: 8-iso-PGE1 from 56.9 2-iso- PGE2 increased from 51.6 to 8.6; 8-iso-PGE2 increased from 51.6 to 9.2; PGE2 increased from 61.2 to 2.9; sulprostone increased from 55.9 to 18.8. |
| Animal Protocol |
Animal/Disease Models: Male db/db mice [3]
Doses: 50 and 100 μg/kg Route of Administration: po (oral gavage); 50 and 100 μg/kg; one time/day; 8 weeks Experimental Results: Inhibited fasting of db/db mice An increase in blood sugar levels. Suppression of increased pro-inflammatory gene expression in adipocytes isolated from epididymal AT of db/db mice. |
| References |
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| Additional Infomation |
L-798106 is an N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of o-naphthalen-2-ylcinnamic acid with the sulfonamide group of 5-bromo-2-methoxybenzenesulfonamide. It is a selective antagonist for the prostanoid receptor EP3, a prostaglandin receptor for prostaglandin E2 (PGE2). It has a role as a prostaglandin receptor antagonist. It is a N-sulfonylcarboxamide, a member of bromobenzenes and an aromatic ether.
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| Molecular Formula |
C27H22BRNO4S
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|---|---|
| Molecular Weight |
536.44
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| Exact Mass |
535.045
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| CAS # |
244101-02-8
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| PubChem CID |
15551229
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| Appearance |
White to off-white solid powder
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| Density |
1.425±0.06 g/cm3(Predicted)
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| LogP |
7.191
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
34
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| Complexity |
810
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=C(C=C(C=C1)Br)S(=O)(=O)NC(=O)/C=C/C2=CC=CC=C2CC3=CC4=CC=CC=C4C=C3
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| InChi Key |
ODTKFNUPVBULRJ-NTCAYCPXSA-N
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| InChi Code |
InChI=1S/C27H22BrNO4S/c1-33-25-14-13-24(28)18-26(25)34(31,32)29-27(30)15-12-21-7-3-5-9-23(21)17-19-10-11-20-6-2-4-8-22(20)16-19/h2-16,18H,17H2,1H3,(H,29,30)/b15-12+
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| Chemical Name |
(E)-N-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide
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| Synonyms |
L798,106; L 798,106; L-798,106
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~10 mg/mL (~18.64 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8641 mL | 9.3207 mL | 18.6414 mL | |
| 5 mM | 0.3728 mL | 1.8641 mL | 3.7283 mL | |
| 10 mM | 0.1864 mL | 0.9321 mL | 1.8641 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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