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|---|---|---|
| Other Sizes |
| Targets |
Knorr-2-Chlorotrityl Resin does not have a specific biological target. Its primary utility is as a solid support in peptide synthesis, particularly in the Fmoc strategy. The resin is used to anchor the growing peptide chain, allowing for stepwise peptide assembly. After peptide synthesis is complete, the peptide can be cleaved from the resin under mild acidic conditions. It does not have a therapeutic target but is a key reagent in peptide chemistry.
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|---|---|
| ln Vitro |
Knorr-2-Chlorotrityl Resin does not exhibit pharmacological activity in vitro. As a solid support for peptide synthesis, it is a chemical reagent rather than a bioactive compound. In vitro studies using this resin focus on its chemical properties, such as its loading capacity and cleavage efficiency. The resin is used in the synthesis of peptides, which may have biological activity, but the resin itself is not active. Its role in research is as a tool for peptide synthesis.
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| ln Vivo |
Knorr-2-Chlorotrityl Resin is not a pharmacologically active compound and therefore does not have defined in vivo activity as a drug. Its primary value is as a chemical reagent for peptide synthesis. It is not intended for in vivo administration in any therapeutic context. Its use is confined to the laboratory, where it serves as a solid support for the preparation of peptides and peptide-based pharmaceuticals.
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| Enzyme Assay |
In vitro assays for Knorr-2-Chlorotrityl Resin are focused on its chemical properties and its use in peptide synthesis. Standard protocols involve the use of this resin as a solid support in Fmoc-based solid-phase peptide synthesis (SPPS). The resin is typically swollen in a solvent such as DMF or DCM, and the first amino acid is coupled to the resin. The progress of the peptide synthesis is monitored by standard methods such as the Kaiser test. The cleavage of the peptide from the resin is achieved under mild acidic conditions.
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| Cell Assay |
In vitro cellular assays using Knorr-2-Chlorotrityl Resin are not performed, as the compound is a solid support used in chemical synthesis rather than a bioactive molecule. Its use is confined to the laboratory for peptide synthesis. The peptides synthesized on this resin may be tested in cellular assays, but the resin itself is not designed for cell culture studies.
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| Animal Protocol |
In vivo animal studies with Knorr-2-Chlorotrityl Resin are not conducted, as the compound is a chemical reagent rather than a pharmacologically active agent. Its use is confined to the laboratory for peptide synthesis. The peptides synthesized on this resin may be evaluated in animal models, but the resin itself is not administered in vivo.
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| ADME/Pharmacokinetics |
Knorr-2-Chlorotrityl Resin is not a drug candidate, and pharmacokinetic data are not available. As a solid support for peptide synthesis, it is designed for use in chemical synthesis rather than systemic administration. Its use is confined to in vitro synthetic applications.
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| Toxicity/Toxicokinetics |
Knorr-2-Chlorotrityl Resin is generally considered to have low toxicity, consistent with its use as a chemical reagent. It is a chlorinated organic compound and should be handled with care. Standard laboratory safety precautions, including the use of personal protective equipment, are recommended. It is not classified as a highly toxic substance, but appropriate safety measures should be followed. Inhalation, ingestion, or skin contact should be avoided.
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| Additional Infomation |
Knorr-2-Chlorotrityl Resin (2-Chlorotrityl Chloride, CAS 42074-68-0) is an extremely acid-labile resin used for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Its molecular formula is C₁₉H₁₄Cl₂ and its molecular weight is 313.22 g/mol. It appears as an off-white to light yellow solid powder with a purity of ≥98%. It is used in convergent peptide synthesis. It is intended for research use only.
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| Molecular Formula |
C19H14CL2
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|---|---|
| Molecular Weight |
313.2205
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| Exact Mass |
312.047
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| CAS # |
42074-68-0
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| PubChem CID |
94524
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.222±0.06 g/cm3
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| Boiling Point |
421.3±40.0 °C at 760 mmHg
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| Melting Point |
136 ºC (benzene )
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| Flash Point |
194.2±20.9 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.614
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| LogP |
6.16
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
0
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
21
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| Complexity |
298
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC(C1C([H])=C([H])C([H])=C([H])C=1[H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
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| InChi Key |
JFLSOKIMYBSASW-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
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| Chemical Name |
1-chloro-2-[chloro(diphenyl)methyl]benzene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1926 mL | 15.9632 mL | 31.9264 mL | |
| 5 mM | 0.6385 mL | 3.1926 mL | 6.3853 mL | |
| 10 mM | 0.3193 mL | 1.5963 mL | 3.1926 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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