| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| 10g |
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| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Absorption efficiency depends on the form of the iron salt, the dosage, the administration regimen, and the iron reserve. Subjects with normal iron reserves can absorb 10% to 35% of iron supplements. Individuals with iron deficiency can absorb up to 95% of iron supplements. |
|---|---|
| Additional Infomation |
Ferrous fumarate is a dicarboxylic acid. It is used to treat iron deficiency anemia. Ferrous fumarate is the fumarate form of mineral iron. Taking ferrous fumarate increases serum iron concentration, which is then absorbed into hemoglobin (essential for oxygen transport) or captured and stored by reticuloendothelial cells. This medication is used as a dietary supplement and for the prevention or treatment of iron deficiency-related syndromes. See also: Iron (with active moiety); Ferrous cation (with active moiety); Ethinyl estradiol; Ferrous fumarate; Norethindrone (ingredient)... See more...
Drug Indications For the prevention and treatment of iron deficiency anemia. Mechanism of Action Iron is essential for hemoglobin production. Iron deficiency leads to reduced hemoglobin production and causes microcytic hypochromic anemia. |
| Molecular Formula |
C4H2FEO4
|
|---|---|
| Molecular Weight |
169.9
|
| Exact Mass |
169.93
|
| CAS # |
141-01-5
|
| Related CAS # |
7705-12-6 (unspecified iron(+2) salt);110-17-8 (Parent);15438-31-0 (Parent);141-01-5 (Parent)
|
| PubChem CID |
6433164
|
| Appearance |
Light brown to brown solid powder
|
| Density |
2.435
|
| Melting Point |
>280°C
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
0
|
| Heavy Atom Count |
9
|
| Complexity |
108
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Fe+2].O=C(/C=C/C([O-])=O)[O-]
|
| InChi Key |
PMVSDNDAUGGCCE-TYYBGVCCSA-L
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| InChi Code |
InChI=1S/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;
|
| Chemical Name |
(E)-but-2-enedioate;iron(2+)
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~1 mg/mL (~5.89 mM)
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8858 mL | 29.4291 mL | 58.8582 mL | |
| 5 mM | 1.1772 mL | 5.8858 mL | 11.7716 mL | |
| 10 mM | 0.5886 mL | 2.9429 mL | 5.8858 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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