| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
IR-797 chloride does not have a specific biological receptor target. Its primary function is as a fluorescent dye with near-infrared properties. When conjugated to nanoparticles or used as a photosensitizer, it can be activated by light to induce cytotoxic effects, making it useful for photodynamic therapy. Its AIE properties enhance fluorescence in aggregated states, which is beneficial for imaging applications.
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| ln Vitro |
After self-assembling into nanoparticles, hydrophobic IR-797 molecules are surface-modified with an amphiphilic polymer (C18PMH-PEG5000) [1]. IR-797 can be utilized as a chemotherapeutic medication to cause cancer cells to undergo apoptosis and to create PEG-IR-797 nanoparticles [1].
In vitro, IR-797 chloride shows cytotoxic activity against cancer cells. It can be used to make PEG-IR-797 nanoparticles that act as chemotherapeutic drugs inducing apoptosis. The compound's photodynamic properties allow it to be activated by light to target cancer cells. Specific IC₅₀ values or detailed cytotoxicity data are not provided in the available sources. |
| ln Vivo |
Specific in vivo activity data for IR-797 chloride are not detailed in the available sources. As a NIR dye with photodynamic and chemotherapeutic potential, it would be expected to have applications in imaging and therapy in animal models. Its use in making PEG-IR-797 nanoparticles suggests potential for in vivo drug delivery and imaging studies. However, no specific in vivo results are provided.
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| Enzyme Assay |
A cell-free assay for IR-797 chloride is not applicable as it is not an enzyme inhibitor or receptor ligand. Its properties are characterized by spectroscopic methods. Its absorption maximum near 700 nm and AIE properties can be measured in solution. The compound's ability to generate reactive oxygen species upon light activation, which is relevant for photodynamic therapy, could be assessed in cell-free systems using probes such as singlet oxygen sensors.
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| Cell Assay |
Cellular assays for IR-797 chloride typically involve assessing its cytotoxicity and uptake in cancer cell lines. Cells are incubated with the compound or PEG-IR-797 nanoparticles, and cell viability is measured using assays such as MTT or apoptosis detection. The compound's photodynamic activity can be evaluated by irradiating cells after treatment and measuring cell death. Specific protocols are not detailed in the available sources.
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| Animal Protocol |
In vivo animal experiments for IR-797 chloride are not described in the available sources. As a compound with potential for photodynamic therapy and imaging, it would likely be evaluated in tumor-bearing mouse models. In such studies, the compound or its nanoparticle formulations would be administered, and tumor growth and fluorescence signals would be monitored. However, specific protocols and data are not provided.
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| ADME/Pharmacokinetics |
IR-797 chloride is a small molecule dye with a molecular weight of 505.52. Its pharmacokinetic properties are not reported in the available sources. As a NIR dye, its biodistribution would be influenced by its formulation, such as conjugation to PEG nanoparticles. General storage recommendations for the compound are not provided in the available sources.
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| Toxicity/Toxicokinetics |
Toxicity data for IR-797 chloride are not provided in the available sources. The compound exhibits cytotoxic activity against cancer cells, but its selectivity and safety profile have not been established. As with all research compounds, it is intended for research use only and not for human consumption. Standard laboratory safety precautions should be observed when handling this compound.
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| References | |
| Additional Infomation |
IR-797 chloride (CAS: 110992-55-7) is a near-infrared (NIR) dye with aggregation-induced emission (AIE) properties. It has an absorption maximum near 700 nm. The compound can be used to formulate PEG-IR-797 nanoparticles and has been investigated as a chemotherapeutic agent that induces apoptosis in cancer cells. It is also utilized in photodynamic therapy and targeted drug delivery research. Its molecular formula is C₃₁H₃₄Cl₂N₂ with a molecular weight of 505.52. It is not an approved drug and is strictly for research purposes.
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| Molecular Formula |
C31H34CLN2.CL
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|---|---|
| Molecular Weight |
505.52100
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| Exact Mass |
504.21
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| CAS # |
110992-55-7
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| PubChem CID |
56925144
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| Appearance |
Light brown to brown solid powder
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| Melting Point |
116.7-128.0ºC(lit.)
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| LogP |
4.801
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
35
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| Complexity |
915
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| Defined Atom Stereocenter Count |
0
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9782 mL | 9.8908 mL | 19.7816 mL | |
| 5 mM | 0.3956 mL | 1.9782 mL | 3.9563 mL | |
| 10 mM | 0.1978 mL | 0.9891 mL | 1.9782 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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