| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| 5g |
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| Other Sizes |
| Targets |
Hexaflumuron targets chitin synthesis in insects. Chitin is a vital structural component of the insect exoskeleton. By inhibiting chitin synthesis, Hexaflumuron disrupts the formation of the exoskeleton during molting, leading to the death of the insect. Termites are unable to metabolize Hexaflumuron, and its clearance is slow, resulting in up to 100% elimination of the colony.
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| ln Vitro |
Hexaflumuron is not used in traditional pharmacological activity assays. Its activity is assessed in insect bioassays. It exhibits high insecticidal activity against a broad spectrum of pests, with a strong knockdown effect and rapid action. Its effectiveness as a chitin synthesis inhibitor is confirmed by its ability to prevent molting and cause mortality in treated insects.
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| ln Vivo |
Hexaflumuron is used in vivo as a pest control agent. It is applied to crops to control insect pests. As a termiticide, it is used in baiting systems to eliminate entire termite colonies. The compound spreads efficiently through termite populations via mutual exchange of liquids, allowing it to reach and eliminate the colony.
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| Enzyme Assay |
Hexaflumuron does not have a typical enzyme/receptor binding assay. Its activity is assessed in insect bioassays. Insects or their eggs are exposed to the compound, and the inhibition of molting, egg hatching, or development is measured. The effects on chitin synthesis can be assessed by measuring chitin content in treated insects.
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| Cell Assay |
Hexaflumuron is not typically used in cell-based assays for pharmacological purposes. Its effects are studied in insect models. The compound's effects on insect cell lines can be assessed by measuring chitin synthesis or cell viability. However, its primary applications are in pest control rather than cellular research.
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| Animal Protocol |
In vivo animal experiments for Hexaflumuron are conducted to assess its efficacy as an insecticide. It is tested in field trials on crops or in laboratory settings against insect pests. Its effectiveness in controlling pest populations and its environmental impact are evaluated.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
This substance can be absorbed by the human body through inhalation. Hexaflumuron has a molecular weight of 461.14 g/mol and a molecular formula of C16H8Cl2F6N2O3. It is a solid with a melting point of 197-199°C. It is soluble in DMF and DMSO. It is very toxic to aquatic organisms and may bioaccumulate in fish. |
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Rat) > 2,500 mg/m³/4h Non-human Toxicity Values LD50 (Rats, Oral) > 5000 mg/kg LD50 (Rats, Dermal) > 5000 mg/kg Hexaflumuron has low toxicity to mammals but is very toxic to aquatic organisms. It is not intended for human use and is classified as a pesticide. Its safety for use in agriculture has been established through regulatory review. It is available from various chemical suppliers for research purposes. |
| Additional Infomation |
Hexaflurium is an N-acylurea compound with a urea-like structure, in which one nitrogen atom has a hydrogen atom replaced by a 2,6-difluorobenzoyl group, and the other nitrogen atom has a hydrogen atom replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group. It is a benzoylurea insecticide, organofluorine insecticide, organochlorine insecticide, dichlorobenzene compound, N-acylurea compound, and aromatic ether compound.
Hexaflumuron is a benzoylurea insecticide and chitin synthesis inhibitor used for pest control. It is effective against a wide range of insect pests and is used as a termiticide. Its mechanism of action involves inhibiting chitin synthesis, which disrupts molting and leads to insect death. It is available from various chemical suppliers for research purposes. |
| Molecular Formula |
C16H8CL2F6N2O3
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|---|---|
| Molecular Weight |
461.1414
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| Exact Mass |
459.981
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| CAS # |
86479-06-3
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| PubChem CID |
91741
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| Appearance |
White solid
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| Density |
1.6±0.1 g/cm3
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| Melting Point |
202-205ºC
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| Index of Refraction |
1.548
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| LogP |
5.87
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
29
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| Complexity |
581
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(NC1C=C(Cl)C(OC(C(F)F)(F)F)=C(Cl)C=1)NC(C1C(F)=CC=CC=1F)=O
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| InChi Key |
RGNPBRKPHBKNKX-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H8Cl2F6N2O3/c17-7-4-6(5-8(18)12(7)29-16(23,24)14(21)22)25-15(28)26-13(27)11-9(19)2-1-3-10(11)20/h1-5,14H,(H2,25,26,27,28)
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| Chemical Name |
N-[[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]carbamoyl]-2,6-difluorobenzamide
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| Synonyms |
XRD 473; XRD-473; Hexaflumuron
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~542.13 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1685 mL | 10.8427 mL | 21.6854 mL | |
| 5 mM | 0.4337 mL | 2.1685 mL | 4.3371 mL | |
| 10 mM | 0.2169 mL | 1.0843 mL | 2.1685 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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