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| Other Sizes |
| Targets |
H-Phg-ol is a chiral building block and biochemical reagent used in organic synthesis and biomedical research. It does not have a specific biological receptor target. Its primary applications include the synthesis of chiral, unsymmetrical bisoxazolines and as a reagent for the resolution of acids via easily hydrolyzed amides. The compound's chirality makes it valuable for preparing enantiomerically pure compounds and studying stereoselective biochemical processes.
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|---|---|
| ln Vitro |
H-forms glycinol
In vitro activity for H-Phg-ol is not applicable as a standalone biological agent. It functions as a chemical reagent and chiral building block. It is not typically used directly in biological assays. Its value lies in the synthesis of other molecules, such as chiral ligands and pharmaceutical intermediates, that may possess biological activity. Amino acid derivatives have been studied as ergogenic supplements, but this is not a primary application for H-Phg-ol. |
| ln Vivo |
In vivo activity data for H-Phg-ol as a standalone compound is not applicable. It is a research reagent and building block, not a drug candidate for direct administration. The compound may be used to synthesize molecules that are subsequently evaluated in animal models. The primary amine and alcohol functionalities make it a versatile intermediate for further chemical modifications to create target compounds for pharmaceutical research.
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| Enzyme Assay |
In vitro protocols for H-Phg-ol are primarily synthetic. It is used as a starting material in organic synthesis, for example, in the preparation of chiral bisoxazoline ligands. Standard procedures involve its conversion to various derivatives through reactions of the amine or alcohol groups. It can also be used as a chiral resolving agent. Purity is typically ≥98%. The compound is soluble in DMSO and other organic solvents.
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| Cell Assay |
Cell-based protocols are not applicable to H-Phg-ol as it is a synthetic building block and not typically used in cell culture. It is a chiral amino alcohol used as a reagent in organic synthesis. Biological testing would be performed on the final compounds synthesized from this intermediate. The compound should be handled as a standard laboratory chemical.
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| Animal Protocol |
Animal studies are not conducted with H-Phg-ol directly. The compound may be used as a synthetic intermediate to prepare compounds for pharmaceutical research. Standard synthetic chemistry protocols are used to convert this intermediate into target molecules for potential in vivo evaluation. Any animal studies would be performed on the final drug candidates derived from this building block.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of H-Phg-ol are not applicable as it is a research intermediate. The compound has a molecular weight of 137.18 g/mol, a calculated LogP of 0.42, and is soluble in DMSO. It has a melting point of 75-79°C and a boiling point of 261°C. Storage is recommended at -20°C for long-term stability. The compound is stable at room temperature for short periods during shipping.
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| Toxicity/Toxicokinetics |
Limited toxicological data indicates H-Phg-ol can cause serious eye damage and severe skin burns. The compound is for research use only. Standard safety precautions for handling chemicals should be observed, including wearing protective equipment. In case of ingestion, do not induce vomiting. No specific systemic toxicity studies have been reported. It is not intended for human therapeutic use.
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| Additional Infomation |
H-Phg-ol (CAS#: 20989-17-7) is also known as (S)-(+)-2-Phenylglycinol, L-2-phenylglycinol, and (2S)-2-amino-2-phenylethanol. Its molecular formula is C8H11NO. It is a chiral building block used in the synthesis of chiral ligands and as a resolving agent. It has no approved therapeutic indications and is not in clinical trials.
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| Molecular Formula |
C8H11NO
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|---|---|
| Molecular Weight |
137.1790
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| Exact Mass |
137.084
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| CAS # |
20989-17-7
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| PubChem CID |
134797
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| Appearance |
White to light yellow powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
261.0±0.0 °C at 760 mmHg
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| Melting Point |
75-79ºC
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| Flash Point |
125.3±21.8 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.572
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| LogP |
0.42
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
10
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| Complexity |
89.3
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| Defined Atom Stereocenter Count |
1
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| SMILES |
O([H])C([H])([H])[C@]([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])[H]
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| InChi Key |
IJXJGQCXFSSHNL-MRVPVSSYSA-N
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| InChi Code |
InChI=1S/C8H11NO/c9-8(6-10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2/t8-/m1/s1
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| Chemical Name |
(2S)-2-amino-2-phenylethanol
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| Synonyms |
H-Phg-ol; (S)-(+)-2-Phenylglycinol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~729.0 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (36.45 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 5 mg/mL (36.45 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 5 mg/mL (36.45 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (50.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL | |
| 5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL | |
| 10 mM | 0.7290 mL | 3.6448 mL | 7.2897 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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