| Size | Price | |
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| Other Sizes |
| Targets |
As a protected phenylalanine derivative, H-Phe-Oall·TosOH does not have a specific biological target. Its primary utility is as a chemical building block in organic synthesis, particularly in peptide chemistry. The compound serves as a protected phenylalanine unit that can be incorporated into peptide chains while the allyl ester protects the C-terminus. Phenylalanine is an essential amino acid that is a precursor for tyrosine, dopamine, norepinephrine, and epinephrine, but in its protected form, the compound is not designed to interact with biological receptors. Its value lies in its chemical properties as a synthetic intermediate.
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| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
H-Phe-Oall·TosOH does not exhibit pharmacological activity in vitro. As a protected amino acid derivative, it is a synthetic intermediate rather than a bioactive compound. Its role in research is almost exclusively as a reagent for organic synthesis. |
| ln Vivo |
H-Phe-Oall·TosOH is not a pharmacologically active compound and therefore does not have defined in vivo activity as a drug. Its primary value remains in synthetic chemistry.
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| Enzyme Assay |
In vitro assays for H-Phe-Oall·TosOH focus on its chemical reactivity in peptide synthesis. The allyl ester can be selectively removed using palladium catalysts (e.g., Pd(PPh₃)₄) in the presence of a nucleophile such as morpholine or N-methylaniline.
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| Cell Assay |
In vitro cellular assays using H-Phe-Oall·TosOH are not commonly performed.
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| Animal Protocol |
In vivo animal studies with H-Phe-Oall·TosOH are not conducted.
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| ADME/Pharmacokinetics |
H-Phe-Oall·TosOH is not a drug candidate, and pharmacokinetic data are not available.
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| Toxicity/Toxicokinetics |
The compound is generally considered to have low toxicity. It should be stored at -20°C for long-term stability.
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| References |
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-887.
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| Additional Infomation |
See also: L-phenylalanine methyl ester (note moved to).
H-Phe-Oall·TosOH (CAS 7524-50-7) is a protected phenylalanine derivative used as a building block in peptide synthesis. Its chemical formula is C₁₀H₁₄ClNO₂ and molecular weight is 215.68. It is intended for research use only. |
| Molecular Formula |
C10H14CLNO2
|
|---|---|
| Molecular Weight |
215.6767
|
| Exact Mass |
215.071
|
| CAS # |
7524-50-7
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| PubChem CID |
75736
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
264.2ºC at 760 mmHg
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| Melting Point |
156-160ºC
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| Flash Point |
126ºC
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| Index of Refraction |
38 ° (C=2， EtOH)
|
| LogP |
2.231
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
14
|
| Complexity |
164
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
Cl[H].O(C([H])([H])[H])C([C@]([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])[H])=O
|
| InChi Key |
SWVMLNPDTIFDDY-FVGYRXGTSA-N
|
| InChi Code |
InChI=1S/C10H13NO2.ClH/c1-13-10(12)9(11)7-8-5-3-2-4-6-8;/h2-6,9H,7,11H2,1H3;1H/t9-;/m0./s1
|
| Chemical Name |
methyl (2S)-2-amino-3-phenylpropanoate;hydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6365 mL | 23.1825 mL | 46.3650 mL | |
| 5 mM | 0.9273 mL | 4.6365 mL | 9.2730 mL | |
| 10 mM | 0.4636 mL | 2.3182 mL | 4.6365 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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