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| Targets |
H-DL-Ser-OMe.HCl is classified as a serine analogue and a racemic amino acid derivative. It does not have a specific biological receptor target. Its primary application is as a synthetic building block in organic and peptide chemistry. As a racemic mixture, it contains both D- and L-enantiomers and can be used to study stereochemical effects or can be resolved into its individual enantiomers for stereospecific applications.
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| ln Vitro |
Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. They are regarded as advantageous synergistic food ingredients [1].
In vitro activity for H-DL-Ser-OMe.HCl is primarily as a synthetic intermediate. Commercial ergot supplements have been made from amino acids and their derivatives. They affect the release of anabolic hormones, the availability of fuel for activity, the ability to think clearly under pressure, and the prevention of muscular damage brought on by exertion. H-DL-Ser-OMe.HCl itself is not directly biologically active; its utility is in preparing serine-containing compounds for subsequent evaluation. |
| ln Vivo |
In vivo activity data for H-DL-Ser-OMe.HCl as a standalone compound is not applicable. It is a racemic amino acid ester used as a research building block and is not intended for direct in vivo administration. Compounds synthesized using this building block may be evaluated in animal models for various biological activities. The methyl ester is typically hydrolyzed before biological testing.
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| Enzyme Assay |
In vitro synthetic protocols for H-DL-Ser-OMe.HCl involve its use as a building block for chemical synthesis. The compound is used as a reactant in the preparation of chicoric acid analogs as HIV-1 integrase inhibitors and in the total synthesis of (-)-Hennoxazole A. The methyl ester can be hydrolyzed under basic conditions. Purity is typically ≥95%.
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| Cell Assay |
Cell-based protocols are not directly applicable to H-DL-Ser-OMe.HCl as it is a synthetic building block. Compounds synthesized using this reagent can be tested in cell culture. Compounds are dissolved in DMSO or appropriate buffers and added to cells at concentrations of 0.1-100 µM for 24-72 hours.
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| Animal Protocol |
Animal studies with H-DL-Ser-OMe.HCl are not conducted directly. The compound may be used as a synthetic intermediate to prepare compounds for pharmaceutical research. Standard synthetic chemistry protocols are used to convert this intermediate into target molecules for potential in vivo evaluation.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for H-DL-Ser-OMe.HCl as a standalone compound is not applicable. The compound has a molecular weight of 155.58 g/mol, formula C4H10ClNO3, and CAS number 5619-04-5. It has a melting point of 134-136°C. Storage is recommended as powder at -20°C for up to 3 years.
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| Toxicity/Toxicokinetics |
Limited toxicological data is available for H-DL-Ser-OMe.HCl. The compound is for research use only and is not intended for human therapeutic use. Standard safety precautions for handling laboratory chemicals should be observed. No specific toxicity studies have been reported.
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| References |
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
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| Additional Infomation |
See also: Serine methyl ester (note moved to).
H-DL-Ser-OMe.HCl (CAS#: 5619-04-5) is also known as methyl DL-serinate hydrochloride and 2-amino-3-hydroxypropanoic acid methyl ester hydrochloride. Its molecular formula is C4H10ClNO3. It is a serine analogue used as a synthetic intermediate. It has no approved therapeutic indications. |
| Molecular Formula |
C4H10CLNO3
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|---|---|
| Molecular Weight |
155.5801
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| Exact Mass |
147.104
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| CAS # |
5619-04-5
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| PubChem CID |
517373
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| Appearance |
White to off-white powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
239.3±9.0 °C at 760 mmHg
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| Melting Point |
134-136 °C(lit.)
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| Flash Point |
100.0±14.2 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.522
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| LogP |
1.9
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
9
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| Complexity |
83.4
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| Defined Atom Stereocenter Count |
0
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| SMILES |
Cl[H].O(C([H])([H])[H])C(C([H])(C([H])([H])O[H])N([H])[H])=O
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| InChi Key |
NDBQJIBNNUJNHA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H9NO3.ClH/c1-8-4(7)3(5)2-6;/h3,6H,2,5H2,1H3;1H
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| Chemical Name |
methyl 2-amino-3-hydroxypropanoate;hydrochloride
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| Synonyms |
H-DL-Ser-OMe.HCl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~214.23 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.4276 mL | 32.1378 mL | 64.2756 mL | |
| 5 mM | 1.2855 mL | 6.4276 mL | 12.8551 mL | |
| 10 mM | 0.6428 mL | 3.2138 mL | 6.4276 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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