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    GRP 60367
    GRP 60367

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2214
    CAS #: 1309241-34-6Purity ≥98%

    Description: GRP 60367 is a novel,potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell-to-cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a recombinant VSV backbone resulted in the recovery of replication-competent virions with low susceptibility to the inhibitor.

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    Molecular Formula: C21H27N3O2
    Exact Mass: 353.2103
    Molecular Weight: 353.466
    Elemental Analysis: C, 71.36; H, 7.70; N, 11.89; O, 9.05





    Synonym: GRP-60367; GRP 60367; GRP60367;

    Chemical Name: (4-((2-(2,5-dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone

    InChi Key: WNJMKSOJWRDLLM-UHFFFAOYSA-N

    InChi Code: InChI=1S/C21H27N3O2/c1-16-3-4-17(2)20(15-16)26-14-11-23-19-7-12-24(13-8-19)21(25)18-5-9-22-10-6-18/h3-6,9-10,15,19,23H,7-8,11-14H2,1-2H3

    SMILES Code: O=C(N1CCC(NCCOC2=CC(C)=CC=C2C)CC1)C3=CC=NC=C3


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