| Size | Price | Stock | Qty |
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| 100mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
In addition to acting as a carbon source for cellular oxidation, L-glutamine peptide is a crucial precursor for the synthesis of proteins, amino acids, purine peptides, tandem peptides, and nucleotides. 0.7 mM of L-glutamine and 20 μM of L-glutamic acid are the body's most abundant extracellular forms of the amino acid [1]. After treating BRIN-BD11 cells with 10 mM L-glutamine for 24 hours in culture, 148 genes showed an increase in gene expression of more than 1.8 fold, while 18 genes showed a decrease in gene expression of more than 1.8 fold when compared with 1 mM. Many of these genes included those involved in signaling arousal, apoptosis, gene-regulated genes, and the island death response. The Ca2+-regulated phosphatases calcineurin and trypsin Pdx1 are activated more by L-glutamine [2].
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| References |
[1]. Mary Corless , et al. Glutamine Regulates Expression of Key Transcription Factor, Signal Transduction, Metabolic Gene, and Protein Expression in a Clonal Pancreatic Beta-Cell Line. J Endocrinol. 2006 Sep;190(3):719-27.
[2]. Newsholme P, et al. Glutamine and glutamate as vital metabolites. Braz J Med Biol Res. 2003 Feb;36(2):153-63. Epub 2003 Jan 29. |
| Molecular Formula |
C5H10N2O3
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|---|---|
| Molecular Weight |
146.14
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| Exact Mass |
146.0691
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| CAS # |
56-85-9
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| Related CAS # |
D-Glutamine;5959-95-5;DL-Glutamine;6899-04-3;L-Glutamine-15N;80143-57-3;L-Glutamine-13C5;184161-19-1;L-Glutamine-d5;14341-78-7;L-Glutamine-5-13C;159680-32-7;L-Glutamine-1-13C;159663-16-8;L-Glutamine-13C5,15N2;285978-14-5;L-Glutamine-15N2;204451-48-9;L-Glutamine-15N-1;59681-32-2;L-Glutamine-1,2-13C2;L-Glutamine-2-13C;180991-02-0;L-Glutamine-13C5,15N2,d5;2123439-02-9;L-Glutamine-15N2,d5
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| SMILES |
O([H])C([C@]([H])(C([H])([H])C([H])([H])C(N([H])[H])=O)N([H])[H])=O
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| Synonyms |
Glavamin; Glumin; Glutamine
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~33.33 mg/mL (~228.07 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 7.69 mg/mL (52.62 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | |
| 5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | |
| 10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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