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    GLPG-1837
    GLPG-1837

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4568
    CAS #: 1654725-02-6Purity ≥98%

    Description: GLPG1837 (also known as ABBV-974) is a novel, potent and reversible CFTR (cystic fibrosis transmembrane conductance regulator) potentiator with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. Cystic fibrosis (CF) is caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Orkambi, it has been shown that CFTR function can be partially restored by administering one or more small molecules. These molecules aim at either enhancing the amount of CFTR on the cell surface (correctors) or at improving the gating function of the CFTR channel (potentiators). 

    References:  2018 Feb 22;61(4):1425-1435.


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    GLPG-1837

    Name: GLPG1837
    CAS#: 1654725-02-6
    Chemical Formula: C16H20N4O3S
    Exact Mass: 348.1256
    Molecular Weight: 348.42
    Elemental Analysis: C, 55.16; H, 5.79; N, 16.08; O, 13.78; S, 9.20
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABBV-974; ABBV 974; ABBV974; GLPG-1837; GLPG 1837; GLPG1837;
    IUPAC/Chemical Name: N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-3-carboxamide
    InChi Key: GHTGYZMBQPXTCQ-UHFFFAOYSA-N
    InChi Code: InChI=1S/C16H20N4O3S/c1-15(2)7-8-10(12(17)21)14(24-11(8)16(3,4)23-15)19-13(22)9-5-6-18-20-9/h5-6H,7H2,1-4H3,(H2,17,21)(H,18,20)(H,19,22)
    SMILES Code: O=C(C1=NNC=C1)NC(S2)=C(C(N)=O)C3=C2C(C)(C)OC(C)(C)C3


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