| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
FORMAMIDE IS ABSORBED DIRECTLY THROUGH GUINEA PIG SKIN ... . After admin of 2-4 g/rabbit orally, 39% of the dose was recovered unchanged ... . Metabolism / Metabolites THERE APPEARS TO BE GOOD EVIDENCE FOR HYDROLYSIS /OF ALIPHATIC CARBOXYLIC AMIDES/ ... THE SITE OF HYDROLYSIS IS PROBABLY LIVER, WHERE THERE ARE RELATIVELY NONSPECIFIC AMIDASES. RATE OF HYDROLYSIS INCREASES RAPIDLY AS MOLECULAR WT INCREASES ... /EXCEPT/ ACETAMIDE WAS HYDROLYZED MORE SLOWLY THAN FORMAMIDE ... . RELATIVE LACK OF IRRITANT EFFECTS /OF SIMPLE CARBOXYLIC AMIDES/ ON SKIN & MUCOUS MEMBRANES INDICATES THAT HYDROLYSIS IS PROBABLY NOT OCCURRING THERE TO ANY EXTENT, OTHERWISE LOWER MOLECULAR WT ACIDS PRODUCED WOULD CAUSE LOCAL DAMAGE. It is known that dimethylformamide is metabolized in man by sequential N-demethylation to methylformamide & formamide, which are largely eliminated in the urine. In a study ... the hypothesis was tested that formamide undergoes metabolic hydrolysis in rabbits. Acidic substances were titrated after extraction by ether, before & after hydrolysis of urine samples. The ether-soluble acid determined in hydrolyzed urine was assumed to reflect the amount of formamide excreted unchanged. The difference between the amount of amide admin & the total amount excreted unchanged was considered to represent amide which was metabolically hydrolyzed. After admin of 2-4 g/rabbit orally, 39% of the dose was recovered unchanged using this method. |
|---|---|
| Toxicity/Toxicokinetics |
Interactions
FORMAMIDE (3 G/KG IV) HAD LITTLE EFFECT ON CAROTID SINUS REFLEX OR ON HYPERTENSION INDUCED BY EXOGENOUS CATECHOLAMINES, BUT FORMAMIDE DECR HYPERTENSION INDUCED BY INDIRECTLY ACTING AMINES TYRAMINE AND EPHEDRINE. FORMAMIDE, WHEN ADMIN IP TO MICE IN SUBLETHAL DOSES (3.2, 0.77, 2, 1.2, AND 0.75 G/KG), LENGTHENED /CNS DEPRESSION/ ... INDUCED BY 100 MG HEXOBARBITAL, 350 MG CHLORAL, OR 1.4 G URETHANE/KG. Non-Human Toxicity Values LD50 Rat oral 6 g/kg LD50 Rabbit dermal 6 g/kg LD50 Mouse oral 3.15 g/kg LD50 Tumor bearing BDF1 mouse oral 400 mg/kg (given daily for 9 days) For more Non-Human Toxicity Values (Complete) data for FORMAMIDE (8 total), please visit the HSDB record page. |
| References |
|
| Additional Infomation |
Formamide appears as a colorless liquid with a faint odor of ammonia. Denser than water. Freezing point 36 °F. (USCG, 1999)
Formamide is the simplest monocarboxylic acid amide, obtained by formal condensation of formic acid with ammonia. The parent of the class of formaldehydes. It has a role as a solvent. It is a monocarboxylic acid amide, a one-carbon compound and a member of formamides. It is functionally related to a formic acid. It is a tautomer of a formimidic acid. |
| Molecular Formula |
CH₃NO
|
|---|---|
| Molecular Weight |
45.04
|
| Exact Mass |
45.021
|
| CAS # |
75-12-7
|
| Related CAS # |
28704-51-0
|
| PubChem CID |
713
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.0±0.1 g/cm3
|
| Boiling Point |
210.5±9.0 °C at 760 mmHg
|
| Melting Point |
2-3 °C(lit.)
|
| Flash Point |
81.1±18.7 °C
|
| Vapour Pressure |
0.2±0.4 mmHg at 25°C
|
| Index of Refraction |
1.370
|
| LogP |
-1.51
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
3
|
| Complexity |
12.3
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C([H])N([H])[H]
|
| InChi Key |
ZHNUHDYFZUAESO-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3)
|
| Chemical Name |
formamide
|
| Synonyms |
Methanamide; Formimidic acid; Carbamaldehyde
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~2220.25 mM)
H2O : ~100 mg/mL (~2220.25 mM) |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 22.2025 mL | 111.0124 mL | 222.0249 mL | |
| 5 mM | 4.4405 mL | 22.2025 mL | 44.4050 mL | |
| 10 mM | 2.2202 mL | 11.1012 mL | 22.2025 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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