| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 100mg | |||
| 250mg | |||
| Other Sizes |
| Targets |
Fenpropimorph inhibits the sterol pathway in fungi. At low concentrations, it inhibits Δ8-Δ7-sterol isomerase, while at higher levels, it blocks Δ14-sterol reductase, preventing the biosynthesis of ergosterol. Ergosterol is an essential component of fungal cell membranes, and its depletion disrupts membrane integrity and function, leading to fungal growth inhibition and death.
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|---|---|
| ln Vitro |
Fenpropimorph demonstrates fungicidal activity in vitro against various fungal pathogens, including those that cause powdery mildew and rust. Its activity can be assessed using agar diffusion or broth microdilution methods against target fungal species. The compound's effectiveness is measured by determining the minimum inhibitory concentration (MIC) required to inhibit fungal growth.
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| ln Vivo |
Fenpropimorph is used in vivo as a systemic fungicide for the control of powdery mildew and rust in cereal crops. It is also used as a chemical probe for investigating sterol metabolism in both fungal and plant systems. The compound is applied as a spray or other formulation to protect crops from fungal infection.
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| Enzyme Assay |
Non-cellular enzyme assays for fenpropimorph involve assessing its inhibition of Δ8-Δ7-sterol isomerase and Δ14-sterol reductase using fungal enzyme preparations. The enzyme activity is measured by analyzing sterol intermediates using HPLC or GC-MS. IC50 values for enzyme inhibition are determined from dose-response curves.
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| Cell Assay |
In vitro cellular assays for fenpropimorph involve treating fungal cultures (e.g., powdery mildew or rust pathogens) with the compound and assessing growth inhibition. Cultures are incubated with varying concentrations of fenpropimorph, and fungal growth is measured by colony diameter, biomass accumulation, or spectrophotometric methods. MIC values are determined from dose-response curves. The compound's effects on sterol composition can be analyzed by lipid extraction and GC-MS.
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| Animal Protocol |
In vivo animal experiments are not applicable for fenpropimorph as it is an agricultural fungicide rather than a therapeutic compound. Efficacy studies are conducted in plant models rather than animals. Plants infected with fungal pathogens are treated with fenpropimorph, and disease severity is assessed. The compound's systemic activity is evaluated by applying it to roots or leaves and monitoring its distribution and efficacy.
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| ADME/Pharmacokinetics |
Fenpropimorph has a molecular weight of 303.48 and a molecular formula of C20H33NO. It is a liquid at room temperature and is typically stored at room temperature. The compound is soluble in organic solvents such as chloroform and ethyl acetate. Purity is typically ≥98%. It is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Fenpropimorph is generally considered to have low toxicity to mammals at recommended application rates. Standard safety precautions should be followed when handling the compound, as it may cause skin, eye, and respiratory irritation. The compound should be used with caution to avoid exposure to non-target organisms.
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| References |
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| Additional Infomation |
(2S,6R)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine is an alkylbenzene.
Fenpropimorph (CAS 67564-91-4) is a systemic fungicide and sterol biosynthesis inhibitor that targets the ergosterol pathway in fungi. It inhibits Δ8-Δ7-sterol isomerase at low concentrations and Δ14-sterol reductase at higher levels. Fenpropimorph is used for the control of powdery mildew and rust in cereal crops. The compound is available from various commercial suppliers for research and agricultural applications. |
| Molecular Formula |
C20H33NO
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|---|---|
| Molecular Weight |
303.49
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| Exact Mass |
303.256
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| CAS # |
67564-91-4
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| PubChem CID |
93365
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| Appearance |
Colorless to light yellow liquid（Density：0.928±0.06 g/cm3）
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| Density |
0.928 g/cm3
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| Boiling Point |
392.7ºC at 760 mmHg
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| Melting Point |
25°C
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| Flash Point |
115.6ºC
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| Index of Refraction |
1.49
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| LogP |
4.209
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
22
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| Complexity |
317
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| Defined Atom Stereocenter Count |
2
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| SMILES |
CC(CC1=CC=C(C=C1)C(C)(C)C)CN2C[C@H](C)O[C@H](C)C2
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| InChi Key |
RYAUSSKQMZRMAI-ALOPSCKCSA-N
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| InChi Code |
InChI=1S/C20H33NO/c1-15(12-21-13-16(2)22-17(3)14-21)11-18-7-9-19(10-8-18)20(4,5)6/h7-10,15-17H,11-14H2,1-6H3/t15?,16-,17+
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| Chemical Name |
(2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
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| Synonyms |
Fenpropimorphe; Forbel 750; Fenpropimorph
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2950 mL | 16.4750 mL | 32.9500 mL | |
| 5 mM | 0.6590 mL | 3.2950 mL | 6.5900 mL | |
| 10 mM | 0.3295 mL | 1.6475 mL | 3.2950 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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