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Description: Exenatide Acetate (Exendin-4 Acetate), a bioactive peptide composed of 39 amino acids, is antidiabetic medication acting as a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. As a synthetic form of endogenous glucagon-like peptide-1, Exenatide stimulates insulin secretion, inhibits glucagon release, decreases appetite, and slows gastric emptying. As such, it is used as add-on therapy for diabetes mellitus.
References:
[1]. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8.
[2]. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E947-57.
[3]. Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells. Tumour Biol. 2016 Feb;37(2):2647-53.
Related CAS #:141758-74-9 (free base) 141732-76-5 or 914454-01-6 (acetate)
Formula: C₁₈₆H₂₈₆N₅₀O₆₂S
Molecular Weight: 4246.62
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2