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    Exenatide Acetate
    Exenatide Acetate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V34642
    CAS #: 141732-76-5Purity ≥98%

    Description: Exenatide Acetate (Exendin-4 Acetate), a bioactive peptide composed of 39 amino acids, is antidiabetic medication acting as a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. As a synthetic form of endogenous glucagon-like peptide-1, Exenatide stimulates insulin secretion, inhibits glucagon release, decreases appetite, and slows gastric emptying. As such, it is used as add-on therapy for diabetes mellitus.

    References:

    [1]. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8.

    [2]. Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E947-57.

    [3]. Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells. Tumour Biol. 2016 Feb;37(2):2647-53.

    Related CAS #:141758-74-9 (free base)  141732-76-5 or  914454-01-6 (acetate)    

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    Formula: C₁₈₆H₂₈₆N₅₀O₆₂S

    Molecular Weight: 4246.62 


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    These protocols are for reference only. InvivoChem does not independently validate these methods.

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