| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Etoxazole targets the molting process in mites and insects, acting as an insect growth regulator and molting inhibitor. Its mechanism of action involves interference with chitin synthesis or cuticle formation during the molting process, preventing successful ecdysis and leading to death of the target pests. Etoxazole has selective activity against mites and aphids, with low toxicity to non-target organisms. The compound's selective mode of action makes it suitable for integrated pest management programs.
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| ln Vitro |
In vitro, etoxazole is evaluated for its acaricidal and insecticidal activity against target pests. The compound is tested in laboratory bioassays against various mite and aphid species to determine its efficacy and potency. Etoxazole shows activity against eggs, nymphs, and adults of target pests. The compound's effects on molting and development are assessed by observing morphological changes and mortality in treated insects. These studies confirm the compound's mechanism as an insect growth regulator.
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| ln Vivo |
In vivo, etoxazole is an effective acaricide and insecticide used to control mites and insects in various crops, including fruits, vegetables, and ornamental plants. It is an insect growth regulator and molting inhibitor for control of mites and aphids. Etoxazole is characterized by its low toxicity and selective mode of action. The compound is applied as a foliar spray and provides residual activity against target pests. Its efficacy has been demonstrated in field trials and agricultural use. Etoxazole is commercially available as a pesticide.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for etoxazole are not typical, as the compound is an acaricide/insecticide rather than a pharmaceutical agent. Its activity is assessed using standard acaricide and insecticide bioassays. Target pests (e.g., spider mites, aphids) are exposed to varying concentrations of etoxazole, and mortality is recorded over time. The compound's effects on molting are assessed by observing developmental abnormalities. These bioassays confirm the compound's efficacy as an insect growth regulator.
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| Cell Assay |
In vitro cell-based assays for etoxazole are not typically performed, as the compound is an agricultural pesticide rather than a therapeutic agent. Its effects on insect cells can be assessed using cell lines derived from target pests, measuring cell viability and proliferation. However, such assays are not standard for pesticide development. The compound's selectivity and low toxicity are evaluated in toxicological studies using non-target organisms.
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| Animal Protocol |
In vivo animal experiments for etoxazole are conducted in the context of pesticide efficacy and toxicology studies. The compound is applied to plants infested with mites or aphids, and pest mortality is assessed over time. Toxicological studies in mammals have shown low acute toxicity. The compound's environmental fate and effects on non-target organisms are evaluated in regulatory studies. Etoxazole is registered for agricultural use in many countries.
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| ADME/Pharmacokinetics |
Pharmacokinetic (PK) data for etoxazole are primarily derived from toxicological and environmental studies. The compound has a molecular weight of 359.41 g/mol and is a white to light yellow powder. It is lipophilic and has low water solubility. The compound's metabolism and excretion have been studied in the context of pesticide registration. Etoxazole is degraded in the environment through photolysis and microbial degradation. Comprehensive PK data are available from regulatory studies.
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| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (Rats) >1,090 mg/m³/4H Non-human Toxicity Values LD50 (Rats, Dermal Contact) >2000 mg/kg LD50 (Rats, Oral) >5000 mg/kg LD50 (Mice, Oral) >5000 mg/kg /Etoxazole Technical Grade/ /Taken from Table/ LD50 (Rats, Oral) 4274 mg/kg /TetraSan 5 WDG Insecticide/ /Taken from Table/ LD50 (Rats, Dermal Contact) >5000 mg/kg /TetraSan 5 WDG Insecticide/ /Taken from Table/ The toxicity of etoxazole is low for mammals. It is characterized by its low toxicity and selective mode of action. The compound has low acute oral and dermal toxicity in rats. It is not intended for human or veterinary use and is used exclusively as a pesticide. It should be handled with appropriate safety precautions. The compound is registered for agricultural use in many countries. |
| References | |
| Additional Infomation |
Etoxazole is an organofluorine acaricide. It is also an insecticide used to control spider mites on indoor (greenhouse, pergola, and shade houses) ornamental crops (including flowering and foliage crops, ground cover plants, shrubs and trees, as well as non-fruiting fruit and nut trees). Etoxazole belongs to the oxazoline class of insecticides. It kills mite eggs and nymphs and prevents adults from laying eggs. Etoxazole is readily absorbed by plants and transported locally within the leaves. Its insecticidal mechanism of action is the inhibition of chitin biosynthesis. Etoxazole induces molting defects in fall armyworm larvae, similar to benzoyl urea insecticides (a well-known chitin biosynthesis inhibitor).
Etoxazole is a synthetic acaricide and insecticide belonging to the tetrazine chemical class. It is an insect growth regulator and molting inhibitor used for the control of mites and aphids on fruits, vegetables, and ornamentals. Etoxazole is characterized by its low toxicity and selective mode of action. It has a molecular formula of C₂₁H₂₃F₂NO₂ and a molecular weight of 359.41 g/mol. Etoxazole is registered for agricultural use in many countries and is not a pharmaceutical agent. |
| Molecular Formula |
C21H23F2NO2
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| Molecular Weight |
359.4096
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| Exact Mass |
359.169
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| CAS # |
153233-91-1
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| Related CAS # |
Etoxazole-d5
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| PubChem CID |
153974
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| Appearance |
White, crystalline powder
Brown granules /End-use/ |
| Density |
1.2±0.1 g/cm3
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| Boiling Point |
449.1±45.0 °C at 760 mmHg
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| Melting Point |
101-102ºC
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| Flash Point |
225.4±28.7 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.538
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| LogP |
5.85
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
26
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| Complexity |
495
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| Defined Atom Stereocenter Count |
0
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| SMILES |
FC1C([H])=C([H])C([H])=C(C=1C1=NC([H])(C([H])([H])O1)C1C([H])=C([H])C(=C([H])C=1OC([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])F
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| InChi Key |
IXSZQYVWNJNRAL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H23F2NO2/c1-5-25-18-11-13(21(2,3)4)9-10-14(18)17-12-26-20(24-17)19-15(22)7-6-8-16(19)23/h6-11,17H,5,12H2,1-4H3
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| Chemical Name |
4-(4-tert-butyl-2-ethoxyphenyl)-2-(2,6-difluorophenyl)-4,5-dihydro-1,3-oxazole
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7823 mL | 13.9117 mL | 27.8234 mL | |
| 5 mM | 0.5565 mL | 2.7823 mL | 5.5647 mL | |
| 10 mM | 0.2782 mL | 1.3912 mL | 2.7823 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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