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    Etoposide Phosphate (BMY-40481)
    Etoposide Phosphate (BMY-40481)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V13895
    CAS #: 117091-64-2Purity ≥98%

    Description: Etoposide phosphate (BMY40481) is the phosphate salt of Etoposide (known as VP-16 and VP-16213), which is a chemotherapeutic drug used for the treatments of various cancers and is a semisynthetic derivative of podophyllotoxin which inhibits DNA synthesis via topoisomerase II inhibitory activity. Etoposide is extracted from the mandrake root Podophyllum peltatum. It possesses potent antineoplastic properties, and binds to and inhibits topoisomerase II. Etoposide works by ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

    References: J Dermatol Sci. 2000 Nov;24(2):126-33; J Natl Cancer Inst. 1988 Dec 7;80(19):1526-33.

    Related CAS#117091-64-2 (free base)117091-64-2 (phosphate)

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    Molecular Formula: C29H33O16P;

    Exact Mass: 668.15062
    Molecular Weight: 668.54
    Elemental Analysis: C, 52.10; H, 4.98; O, 38.29; P, 4.63

    Synonym: Eposin Etopophos Vepesid VP16. US brand name: Etopophos. Abbreviation: ETOP.

    Chemical Name: [4-[(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] dihydrogen phosphate

    InChi Key: LIQODXNTTZAGID-OCBXBXKTSA-N

    InChi Code: InChI=1S/C29H33O16P/c1-11-38-9-20-27(42-11)23(30)24(31)29(43-20)44-25-14-7-17-16(40-10-41-17)6-13(14)21(22-15(25)8-39-28(22)32)12-4-18(36-2)26(19(5-12)37-3)45-46(33,34)35/h4-7,11,15,20-25,27,29-31H,8-10H2,1-3H3,(H2,33,34,35)/t11-,15+,20-,21-,22+,23-,24-,25-,27-,29+/m1/s1

    SMILES Code: O=P(O)(OC1=C(OC)C=C([[email protected]](C2=C3C=C4OCOC4=C2)[[email protected]@]5([H])C(OC[[email protected]]5([H])[[email protected]@H]3O[[email protected]]6[[email protected]](O)[[email protected]@H](O)[[email protected]]7([H])O[[email protected]](C)OC[[email protected]@]7([H])O6)=O)C=C1OC)O           

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