Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
Etelcalcetide (formerly known as AMG-416, KAI-4169; ONO5163; velcalcetide, trade name Parsabiv) is an FDA approved calcimimetic drug for the treatment of secondary hyperparathyroidism in chronic kidney disease (CKD) patients undergoing hemodialysis. At the conclusion of each dialysis session, it is injected. The way etelcalcetide works is by attaching itself to the parathyroid gland's calcium-sensing receptor and turning it on. Currently, Amgen and Ono Pharmaceuticals in Japan are the owners of Parsabiv. A peptide called etelcalcetide primarily consists of D-amino acids as opposed to the more common L-amino acids. To be more precise, it is the disulfide of L-cysteine with N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide.
Molecular Formula |
C38H73N21O10S2
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Molecular Weight |
1048.26
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Exact Mass |
1047.53
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Elemental Analysis |
C, 43.54; H, 7.02; N, 28.06; O, 15.26; S, 6.12
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CAS # |
1262780-97-1
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Related CAS # |
Etelcalcetide hydrochloride; 1334237-71-6
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Appearance |
Solid powder
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SMILES |
C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@@H](C(=O)O)N)NC(=O)C
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InChi Key |
ANIAZGVDEUQPRI-ZJQCGQFWSA-N
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InChi Code |
InChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1
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Chemical Name |
(2R)-3-[[(2S)-2-acetamido-3-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-oxopropyl]disulfanyl]-2-aminopropanoic acid
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Synonyms |
KAI-4169; KAI4169; KAI 4169; AMG-416; AMG 416; AMG416; ONO5163; ONO 5163; ONO-5163; Etelcalcetide; Velcalcetide; Telcalcetide. Ac-D-Cys-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2.
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80: Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 :Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.9540 mL | 4.7698 mL | 9.5396 mL | |
5 mM | 0.1908 mL | 0.9540 mL | 1.9079 mL | |
10 mM | 0.0954 mL | 0.4770 mL | 0.9540 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT03969329 | Recruiting | Drug: Etelcalcetide | Secondary Hyperparathyroidism | Amgen | December 20, 2019 | Phase 3 |
NCT03633708 | Recruiting | Drug: Etelcalcetide | Secondary Hyperparathyroidism Chronic Kidney Disease |
Amgen | April 29, 2019 | Phase 3 |
NCT03960437 | Completed | Drug: Etelcalcetide | Renal Osteodystrophy Vascular Calcification |
Thomas Nickolas, MD MS | September 6, 2018 | Phase 2 |
NCT03795558 | Completed | Drug: Etelcalcetide | End Stage Renal Disease | Prim. Priv. Doz. Dr. Daniel Cejka | May 1, 2019 | Phase 2 |
NCT01254565 | Completed | Drug: Etelcalcetide Drug: Placebo |
Secondary Hyperparathyroidism | KAI Pharmaceuticals | February 20, 2011 | Phase 2 |