| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 100mg | |||
| Other Sizes |
| Targets |
dulcoside A targets sweet taste receptors (T1R2/T1R3) on the tongue, eliciting a sweet taste sensation. It does not have a therapeutic target but is used as a sweetener. The compound is not metabolized in the human body and is excreted unchanged in the urine and feces.
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|---|---|
| ln Vitro |
Dulcoside A exhibits sweetening activity as a natural sweetener. It is approximately 30-50 times sweeter than sucrose. The compound does not have significant pharmacological activity and is not metabolized in the body. It is used as a sugar substitute in foods and beverages.
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| ln Vivo |
Dulcoside A is not absorbed from the gastrointestinal tract and is excreted unchanged in the urine and feces. It does not affect blood glucose levels, making it suitable for use by individuals with diabetes. The compound is generally recognized as safe (GRAS) as a food ingredient.
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| Enzyme Assay |
In vitro assays for Dulcoside A are not typically performed as it is a food ingredient rather than a therapeutic agent. Taste receptor binding assays can be performed using cells expressing T1R2/T1R3 receptors to study the compound's sweet taste activity.
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| Cell Assay |
In vitro cell-based assays for Dulcoside A are limited. Taste receptor-expressing cell lines can be used to study the compound's activation of sweet taste receptors using calcium flux or other signaling assays. Cytotoxicity assays may be performed to assess safety.
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| Animal Protocol |
In vivo studies for Dulcoside A are primarily toxicological and metabolic. Animal studies have been conducted to assess the safety, metabolism, and excretion of Dulcoside A. The compound is not absorbed and is excreted unchanged.
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| ADME/Pharmacokinetics |
dulcoside A has a molecular weight of 788.87 g/mol and a molecular formula of C₃₈H₆₀O₁₇. It is a white to off-white powder that is soluble in water and ethanol. The compound is stable under normal storage conditions.
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| Toxicity/Toxicokinetics |
Dulcoside A is generally recognized as safe (GRAS) as a food ingredient. It has been extensively studied for safety and is approved for use as a sweetener in many countries. No significant toxicity has been reported at the levels used in foods and beverages.
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| References | |
| Additional Infomation |
Dulcosin A is a diterpenoid glycoside. It has been reported that stevia (Stevia rebaudiana) contains culosin A, and relevant data is available. See also: Stevia rebaudiana leaf (part).
Dulcoside A is a natural sweetener and steviol glycoside found in Stevia rebaudiana. It is approximately 30-50 times sweeter than sucrose and is used as a sugar substitute in foods and beverages. Dulcoside A does not affect blood glucose levels and is suitable for use by individuals with diabetes. Not a drug; used as a food ingredient. |
| Molecular Formula |
C38H60O17
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|---|---|
| Molecular Weight |
788.8728
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| Exact Mass |
788.383
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| CAS # |
64432-06-0
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| PubChem CID |
72941582
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| Appearance |
White to off-white solid powder
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| Density |
1.49±0.1 g/cm3(Predicted)
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| Boiling Point |
928.4±65.0 °C(Predicted)
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| Melting Point |
193 - 195 °C
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| LogP |
-0.7
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| Hydrogen Bond Donor Count |
10
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| Hydrogen Bond Acceptor Count |
17
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
55
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| Complexity |
1430
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| Defined Atom Stereocenter Count |
21
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| SMILES |
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@@]34CC[C@H]5[C@@]6(CCC[C@@]([C@H]6CC[C@]5(C3)CC4=C)(C)C(=O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C)CO)O)O)O)O)O
|
| InChi Key |
CANAPGLEBDTCAF-NTIPNFSCSA-N
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| InChi Code |
InChI=1S/C38H60O17/c1-16-12-37-10-6-20-35(3,8-5-9-36(20,4)34(49)54-32-29(48)26(45)23(42)18(13-39)51-32)21(37)7-11-38(16,15-37)55-33-30(27(46)24(43)19(14-40)52-33)53-31-28(47)25(44)22(41)17(2)50-31/h17-33,39-48H,1,5-15H2,2-4H3/t17-,18+,19+,20-,21-,22-,23+,24+,25+,26-,27-,28+,29+,30+,31-,32-,33-,35+,36+,37+,38-/m0/s1
|
| Chemical Name |
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2676 mL | 6.3382 mL | 12.6764 mL | |
| 5 mM | 0.2535 mL | 1.2676 mL | 2.5353 mL | |
| 10 mM | 0.1268 mL | 0.6338 mL | 1.2676 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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