| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
Purity: =98.6%
| Targets |
Divinyl glycol does not have a single well-defined molecular target but exhibits a range of biological activities. It has been found to have antimicrobial, antifungal, and antitumor properties. The compound has been shown to inhibit the growth of certain cancer cells, suggesting potential activity against cellular proliferation pathways. Its mechanism of action may involve interference with cellular processes essential for microbial and cancer cell survival, but specific molecular targets have not been extensively characterized.
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| ln Vitro |
In vitro, divinyl glycol has demonstrated antimicrobial, antifungal, and antitumor activities. It has been shown to inhibit the growth of certain cancer cells. The compound's ability to inhibit microbial and cancer cell growth suggests that it may interfere with essential cellular processes. Its bioactivity has been confirmed in various in vitro assays. Divinyl glycol is described as a novel and potent bioactive compound.
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| ln Vivo |
In vivo data for divinyl glycol are limited in publicly available sources. As a compound with antimicrobial, antifungal, and antitumor activities, it may have potential therapeutic applications. However, specific in vivo efficacy studies in animal models have not been extensively reported. The compound's potential as a chemotherapeutic agent remains to be fully explored.
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| Enzyme Assay |
In non-cell-based biochemical assays, divinyl glycol's activities are evaluated using standard methods. Antimicrobial and antifungal activities are assessed using susceptibility testing methods such as broth microdilution or agar diffusion assays. Antitumor activity is evaluated using biochemical assays that measure the compound's effects on cancer cell-related enzymes or signaling pathways. These assays provide initial evidence of the compound's biological activities.
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| Cell Assay |
In vitro cellular assays for divinyl glycol involve testing its effects on cultured cells. For antimicrobial and antifungal activity, the compound is tested against bacterial and fungal pathogens using standard microbiological methods. For antitumor activity, cancer cell lines are treated with varying concentrations of divinyl glycol, and cell viability, proliferation, and apoptosis are measured. These assays have demonstrated the compound's ability to inhibit the growth of certain cancer cells.
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| Animal Protocol |
In vivo animal studies for divinyl glycol have not been extensively reported in publicly available sources. As a compound with potential antitumor activity, it would be expected to be evaluated in xenograft tumor models or other disease-relevant animal models. However, specific protocols and data are limited. The compound's development as a potential chemotherapeutic agent would require further in vivo evaluation.
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| ADME/Pharmacokinetics |
Detailed pharmacokinetic properties of divinyl glycol are limited in publicly available sources. The compound has a density of 1.02 g/mL at 25°C, a boiling point of 125°C at 45 mm Hg, and a melting point of 14-16°C. It is soluble in methanol. The compound is stable under normal temperatures and pressures and should be protected from contact with oxidizing agents. Storage should be in tightly closed containers.
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| Toxicity/Toxicokinetics |
14042 rat LD50 oral 1620 uL/kg American Industrial Hygiene Association Journal., 30(470), 1969 [PMID:5823428]
14042 rabbit LD50 skin 400 uL/kg American Industrial Hygiene Association Journal., 30(470), 1969 [PMID:5823428] Toxicological data for divinyl glycol are limited in publicly available sources. As a bioactive compound, it should be handled with appropriate safety precautions. The compound is stable under normal temperatures and pressures and should be protected from contact with oxidizing agents. Its safety profile is consistent with that of other research chemicals used in laboratory settings. |
| References |
[1]. https://pubchem.ncbi.nlm.nih.gov/compound/14042
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| Additional Infomation |
See also: Polycarbophil (monomer); Polycarbophil (monomer).
Divinyl glycol (1,5-hexadiene-3,4-diol) is a bioactive compound with antimicrobial, antifungal, and antitumor activities. It has been shown to inhibit the growth of certain cancer cells and has potential as a chemotherapeutic agent. The compound is also used as a biochemical agent and has found limited use in perfumes. It is a research chemical and is not an approved drug. |
| Molecular Weight |
114.14
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|---|---|
| Exact Mass |
114.068
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| CAS # |
1069-23-4
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| PubChem CID |
14042
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| Appearance |
Typically exists as liquid at room temperature
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
201.9±0.0 °C at 760 mmHg
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| Melting Point |
14-16 °C(lit.)
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| Flash Point |
92.8±0.0 °C
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| Vapour Pressure |
0.1±0.8 mmHg at 25°C
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| Index of Refraction |
1.481
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| LogP |
-0.02
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
8
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| Complexity |
76.5
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C=CC(C(C=C)O)O
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| InChi Key |
KUQWZSZYIQGTHT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H10O2/c1-3-5(7)6(8)4-2/h3-8H,1-2H2
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| Chemical Name |
1,5-Hexadiene,3,4-dihydroxy-
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| Synonyms |
Divinyl glycol; AI3 14412; AI314412; divinyl glycol; Hexa-1,5-diene-3,4-diol; Divinylglycol; 1,5-HEXADIENE,3,4-DIHYDROXY-; 1069-23-4; AI3-14412
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.7612 mL | 43.8059 mL | 87.6117 mL | |
| 5 mM | 1.7522 mL | 8.7612 mL | 17.5223 mL | |
| 10 mM | 0.8761 mL | 4.3806 mL | 8.7612 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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