| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Dilauryl thiodipropionate does not have a specific biological target. As an antioxidant, its mechanism of action is chemical rather than biological, involving the decomposition of hydroperoxides and the scavenging of free radicals to prevent oxidative degradation of polymers. The compound may have some biological antioxidant activity, but this is not its primary application.
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|---|---|
| ln Vitro |
For study pertaining to life sciences, dilauryl thiodipropionate is a biochemical reagent that can be utilized as an organic substance or biological material.
Dilauryl thiodipropionate is not studied for pharmacological activity. In vitro studies are focused on its antioxidant properties in the context of polymer stabilization rather than biological systems. The compound may show antioxidant activity in chemical assays such as DPPH or ABTS, but these are not indicative of biological activity. No significant biological effects have been reported. |
| ln Vivo |
Dilauryl thiodipropionate has no therapeutic activity in vivo. The compound is used as a polymer additive and is not administered to animals for pharmacological purposes. It may be present in materials that come into contact with food or the body, but its primary application is in the plastics industry. No in vivo pharmacological data are available.
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| Enzyme Assay |
In vitro assays for Dilauryl thiodipropionate are typically chemical rather than biological. The compound's antioxidant activity is assessed using standard chemical assays such as DPPH radical scavenging, ABTS, or oxygen radical absorbance capacity (ORAC). Its thermal stability and effectiveness in polymer stabilization are evaluated using differential scanning calorimetry (DSC) or thermogravimetric analysis (TGA).
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| Cell Assay |
Cellular assays for Dilauryl thiodipropionate are not typically performed as the compound is not a drug candidate. If tested, its effects on oxidative stress in cell culture could be assessed. However, the compound is primarily used in the plastics industry and is not studied for biological activity in cell-based systems.
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| Animal Protocol |
Dilauryl thiodipropionate is not used in animal studies as a therapeutic agent. The compound may be evaluated in toxicological studies as part of regulatory requirements for food contact materials or polymer additives. These studies have shown that DLTDP has low toxicity and is not expected to pose significant health risks at the levels used in polymer applications.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Similar to the acid, lauryl thiodipropionate is absorbed from the intestines of dogs, rabbits, and rats, and is mostly excreted via the kidneys as thiodipropionate. Following a single oral administration of 1-(14)C-docosahexadecyl thiodipropionate (107 and 208 mg/kg) to rats, the drug is rapidly excreted, primarily in the urine (85-88%), with a small amount excreted in the feces (1.8-3.5%), and the remainder excreted as (14)CO2 (3-4%, up to day 4). Metabolism/Metabolites Similar to the acid, lauryl thiodipropionate is absorbed from the intestines of dogs, rabbits, and rats, and is mostly excreted via the kidneys as thiodipropionate. Dilauryl thiodipropionate (DLTDP), diceryl thiodipropionate, dimyristyl thiodipropionate, distearate thiodipropionate, and trialkyl thiodipropionate are dialkyl esters of their respective alcohols and thiodipropionic acid (TDPA), respectively, and are used in cosmetics. Ingested DLTDP is excreted in the urine as TDPA. Single-dose acute oral and parenteral administration studies, as well as subchronic and chronic repeated-dose oral studies, showed no significant toxicity. Neither DLTDP nor TDPA irritates the skin or eyes of animals and is not sensitizing. TDPA is neither a teratogen nor a reproductive toxicant. Genotoxicity studies of TDPA and DLTDP were negative. Clinical trials showed some irritation, but no sensitization or photosensitivity was observed. The Cosmetic Ingredient Review Panel considered that the data for DLTDP could be reasonably extrapolated to other dialkyl ester compounds and concluded that these ingredients are safe for use in non-irritating cosmetic formulations. Dilauryl thiodipropionate has a molecular weight of 514.84 g/mol and molecular formula C30H58O4S. It is a white to off-white solid with a melting point of approximately 40-45°C. The compound is soluble in organic solvents and has low solubility in water. It should be stored in a cool, dry place in a tightly sealed container, protected from light and moisture. |
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
Rats: Oral LD50 >2500 mg/kg body weight Mice: Intraperitoneal LD50 >2000 mg/kg body weight Mice: Oral LD50 >2000 mg/kg body weight Dilauryl thiodipropionate has low toxicity and is considered safe for use as a polymer additive and in food contact materials. The compound is not expected to cause significant health effects at the levels used in commercial applications. Standard laboratory safety precautions should be followed when handling the compound. No significant toxicity has been reported. |
| Additional Infomation |
Didodecyl thiodipropionate is a dicarboxylic acid.
Dilauryl thiodipropionate (DLTDP) is a thiodipropionate ester used as a secondary antioxidant and stabilizer in polymer applications. It works synergistically with primary antioxidants to protect polymers from oxidative degradation. The compound is used in plastics, rubbers, and other polymeric materials. DLTDP is not a drug and has no therapeutic applications. It is for research use as a polymer additive or reference standard. |
| Molecular Formula |
C30H58O4S
|
|---|---|
| Molecular Weight |
514.85
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| Exact Mass |
514.405
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| CAS # |
123-28-4
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| PubChem CID |
31250
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| Appearance |
White flakes
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
580.8±35.0 °C at 760 mmHg
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| Melting Point |
40-42 °C(lit.)
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| Flash Point |
264.8±14.0 °C
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| Vapour Pressure |
0.0±1.6 mmHg at 25°C
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| Index of Refraction |
1.472
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| LogP |
12.88
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
30
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| Heavy Atom Count |
35
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| Complexity |
416
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| Defined Atom Stereocenter Count |
0
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| SMILES |
S(C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
| InChi Key |
GHKOFFNLGXMVNJ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C30H58O4S/c1-3-5-7-9-11-13-15-17-19-21-25-33-29(31)23-27-35-28-24-30(32)34-26-22-20-18-16-14-12-10-8-6-4-2/h3-28H2,1-2H3
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| Chemical Name |
dodecyl 3-(3-dodecoxy-3-oxopropyl)sulfanylpropanoate
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| Synonyms |
NSC-65494; NSC 65494; Dilauryl thiodipropionate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9423 mL | 9.7116 mL | 19.4231 mL | |
| 5 mM | 0.3885 mL | 1.9423 mL | 3.8846 mL | |
| 10 mM | 0.1942 mL | 0.9712 mL | 1.9423 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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