| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| ln Vitro |
UV-A radiation is absorbed by diethylaminohydroxybenzoylhexylbenzoate (DHHB), which peaks at 354 nm. Diethylaminohydroxybenzoyl hexyl benzoate's molar absorption coefficient in ethanol at 25°C was determined to be 39 000 mol/dm3/cm at 354 nm. The wavelength of excitation determines the emission spectra of diethylaminohydroxybenzoylhexyl benzoate in ethanol [1].
Diethylamino hydroxybenzoyl hexyl benzoate exhibits strong absorption in the UV-A region (320–400 nm) with a maximum absorption wavelength (λmax) ranging from 354 to 358 nm in different solvents (methanol, ethanol, isopropanol, and octanol). [1] The molar extinction coefficient (ε) of the compound at λmax is approximately 42,000 M⁻¹cm⁻¹, indicating high UV-A absorption capacity. [1] Fluorescence measurements show that the compound has weak fluorescence emission, with a quantum yield (Φf) less than 0.01 in all tested solvents, suggesting efficient non-radiative deactivation of excited states. [1] Photostability assays demonstrate that the compound retains over 95% of its initial absorption intensity after 2 hours of UV-A irradiation (365 nm, 10 mW cm⁻²) in both solution and thin film forms, indicating good photostability. [1] The compound shows high solubility (≥100 mg mL⁻¹) in common organic solvents used in cosmetic formulations, including ethanol, isopropanol, and octanol. [1] |
|---|---|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Based on a rat study evaluating skin or transdermal absorption, only a small amount of diethylaminohydroxybenzoylhexylbenzoate is absorbed transdermally; the majority of the compound remains in the upper stratum corneum. In rat and porcine skin, the transdermal absorption rate was 0.10 ± 0.12 μg/cm² or 0.04 ± 0.05%. No pharmacokinetic data. No pharmacokinetic data. No pharmacokinetic data. Metabolism/Metabolites In in vitro steady-state and transient photolysis experiments, diethylaminohydroxybenzoylhexylbenzoate can be oxidized by H₂O₂/UV to generate degradation products. Like other UV filters, diethylaminohydroxybenzoylhexylbenzoate may undergo photodegradation upon absorption of UV radiation, resulting in a transition from the ground state to a singlet or triplet excited state. Biological Half-Life No pharmacokinetic data. |
| Toxicity/Toxicokinetics |
Protein Binding
No pharmacokinetic data available. |
| References | |
| Additional Infomation |
Diethylaminohydroxybenzoylhexyl benzoate belongs to the benzophenone class of compounds. It is a UV filter with a high absorption rate for the UVA band. It minimizes excessive exposure of human skin to UV radiation, thus preventing acute or chronic photodamage. Diethylaminohydroxybenzoylhexyl benzoate is an oil-soluble UV filter that can be added to the oil phase of emulsions. It was approved for marketing in Europe in 2005 and is currently sold in the United States, South America, Mexico, Japan, and Taiwan. Its chemical structure is similar to classic benzophenone drugs and it has good photostability. In sunscreen products, its concentration can reach up to 10%, and it can be used alone or in combination with other UV absorbers. See also: …See more…
Drug Indications Suitable for use as a sunscreen agent. Mechanism of Action Diethylaminohydroxybenzoylhexylbenzoate absorbs ultraviolet radiation in the UVA band with a peak wavelength of 354 nm. Pharmacodynamics Diethylaminohydroxybenzoylhexylbenzoate is an organic ultraviolet filter that reduces the exposure of human skin to ultraviolet radiation. In vitro experiments have shown that topical application of diethylaminohydroxybenzoylhexylbenzoate can exert an anti-inflammatory effect on the inflammation-induced ear of mice by inhibiting edema formation. Diethylaminohydroxybenzoylhexylbenzoate (trade name: Uvinul A Plus) is a UVA absorber widely used in cosmetics and personal care products. [1] Its main function is to absorb UVA radiation, thereby protecting the skin from ultraviolet damage such as photoaging and DNA damage. [1] This study aims to characterize its photophysical properties (absorption, fluorescence, photostability, solubility) to support its application in sunscreen formulations, as these properties are crucial to the efficacy and stability of sunscreen products. [1] |
| Molecular Formula |
C24H31NO4
|
|---|---|
| Molecular Weight |
397.50724
|
| Exact Mass |
397.225
|
| CAS # |
302776-68-7
|
| PubChem CID |
10111431
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
524.8±40.0 °C at 760 mmHg
|
| Melting Point |
54, Decomposes at 314
|
| Flash Point |
271.2±27.3 °C
|
| Vapour Pressure |
0.0±1.4 mmHg at 25°C
|
| Index of Refraction |
1.565
|
| LogP |
6.93
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
12
|
| Heavy Atom Count |
29
|
| Complexity |
505
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
FDATWRLUYRHCJE-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C24H31NO4/c1-4-7-8-11-16-29-24(28)20-13-10-9-12-19(20)23(27)21-15-14-18(17-22(21)26)25(5-2)6-3/h9-10,12-15,17,26H,4-8,11,16H2,1-3H3
|
| Chemical Name |
hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 50 mg/mL (~125.78 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5157 mL | 12.5783 mL | 25.1566 mL | |
| 5 mM | 0.5031 mL | 2.5157 mL | 5.0313 mL | |
| 10 mM | 0.2516 mL | 1.2578 mL | 2.5157 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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