| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Microbial cell membranes. Decamethoxine is a cationic surfactant that targets the negatively charged phospholipids in microbial cell membranes. The compound disrupts membrane integrity, leading to leakage of intracellular contents and cell death. Its mechanism of action is non-specific and physical, which reduces the likelihood of resistance development. Decamethoxine has broad-spectrum antimicrobial activity.
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| ln Vitro |
Decamethoxine, also known as Septecril, is useful against viruses, protozoa, dermatophytes, Candida, which is a type of yeast-like fungus, and Gram-positive and Gram-negative bacteria, including Pseudomonas, Neisseria gonorrhoeae, and Pneumococcus [1]. At a dosage of 10 µg/ml, decamethoxin markedly decreased the adhesion of Salmonella, Corynebacterium, Staphylococcus, and Escherichia [2].
Decamethoxine has broad-spectrum antimicrobial activity in vitro against Gram-positive and Gram-negative bacteria, fungi, and some viruses. The compound's minimum inhibitory concentrations (MICs) vary depending on the microorganism but are generally in the low micromolar range. The compound is rapidly bactericidal and has been shown to be effective against both planktonic cells and biofilms. |
| ln Vivo |
Decamethoxine has been used as a disinfectant in various settings, including healthcare, food processing, and industrial applications. Its antimicrobial efficacy has been demonstrated in vivo in various disinfection contexts. The compound is not administered systemically as a therapeutic agent but is used topically or as a surface disinfectant. No significant systemic absorption occurs with proper use.
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| Enzyme Assay |
In vitro antimicrobial susceptibility testing for Decamethoxine is performed using broth microdilution or agar dilution methods according to CLSI or EUCAST guidelines. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) are determined against a panel of bacterial and fungal strains. Time-kill assays are performed to assess bactericidal kinetics. Biofilm inhibition and eradication assays are also performed.
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| Cell Assay |
In vitro cell-based assays for Decamethoxine are primarily focused on its antimicrobial activity rather than effects on mammalian cells. However, cytotoxicity assays using mammalian cell lines (e.g., fibroblasts, epithelial cells) are performed to assess the safety profile of the compound for topical use. Cell viability is assessed using MTT or LDH release assays. Hemolysis assays are performed to assess red blood cell compatibility.
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| Animal Protocol |
Decamethoxine is not administered to animals as a therapeutic agent. In vivo studies are focused on its efficacy as a disinfectant in various applications. Animal models of wound infection or skin disinfection may be used to assess the compound's efficacy. Toxicological studies in animals have been performed to assess the safety of the compound for use in healthcare and industrial settings.
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| ADME/Pharmacokinetics |
Decamethoxine has a molecular weight of approximately 629.05 g/mol and molecular formula C38H80N2O4. It is a quaternary ammonium compound that is soluble in water and polar organic solvents. The compound is typically supplied as a solution or concentrate for dilution before use. It should be stored at room temperature in a tightly sealed container, protected from light and moisture.
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| Toxicity/Toxicokinetics |
Decamethoxine has low toxicity at the concentrations used for disinfection. However, the compound can cause skin and eye irritation at higher concentrations. Inhalation of aerosols should be avoided. The compound should be handled with appropriate personal protective equipment. No significant systemic toxicity has been reported with proper use as a disinfectant.
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| References |
[1]. Kovalchuk V, et al. Naturally Drug-Loaded Chitin: Isolation and Applications. Mar Drugs. 2019;17(10):574. Published 2019 Oct 10.
[2]. Nazarchuk OA, et al. The research of antimicrobial efficacy of antiseptics decamethoxin, miramistin and their effect on nuclear DNA fragmentation and epithelial cell cycle. Wiad Lek. 2019;72(3):374-380. |
| Additional Infomation |
Decamethoxine is a quaternary ammonium compound with broad-spectrum antimicrobial activity used as a disinfectant and antiseptic. It disrupts microbial cell membranes through its cationic surfactant properties, leading to cell lysis. The compound is effective against bacteria, fungi, and some viruses and is used in healthcare, food processing, and industrial applications. Decamethoxine is not a drug and has no systemic therapeutic indications. It is for research use as a disinfectant or antimicrobial agent.
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| Molecular Formula |
C38H74CL2N2O4
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|---|---|
| Molecular Weight |
693.92
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| Exact Mass |
692.503
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| Elemental Analysis |
C, 65.77; H, 10.75; Cl, 10.22; N, 4.04; O, 9.22
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| CAS # |
38146-42-8
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| Related CAS # |
17298-14-5 (cation);38146-42-8 (chloride);
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| PubChem CID |
162290
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| Appearance |
Solid powder
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| LogP |
2.276
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
21
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| Heavy Atom Count |
46
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| Complexity |
771
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[Cl-].[Cl-].CC(C1CCC(C)CC1OC(C[N+](CCCCCCCCCC[N+](CC(OC1CC(C)CCC1C(C)C)=O)(C)C)(C)C)=O)C
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| InChi Key |
LRQIWRXCHWNNEA-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/C38H74N2O4.2ClH/c1-29(2)33-21-19-31(5)25-35(33)43-37(41)27-39(7,8)23-17-15-13-11-12-14-16-18-24-40(9,10)28-38(42)44-36-26-32(6)20-22-34(36)30(3)4;;/h29-36H,11-28H2,1-10H3;2*1H/q+2;;/p-2
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| Chemical Name |
10-[dimethyl-[2-(5-methyl-2-propan-2-ylcyclohexyl)oxy-2-oxoethyl]azaniumyl]decyl-dimethyl-[2-(5-methyl-2-propan-2-ylcyclohexyl)oxy-2-oxoethyl]azanium;dichloride
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| Synonyms |
Dekametoksin; Decamethoxine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4411 mL | 7.2054 mL | 14.4109 mL | |
| 5 mM | 0.2882 mL | 1.4411 mL | 2.8822 mL | |
| 10 mM | 0.1441 mL | 0.7205 mL | 1.4411 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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