| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
| Targets |
Cyclo-L-Trp-L-Trp targets bacterial and fungal pathogens. It is an antibiotic that shows antimicrobial activity against a range of bacteria and fungi. It inhibits the growth of multidrug resistant A. baumannii, B. subtilis, Candida albicans, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, and Staphylococcus aureus.
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| ln Vitro |
Cyclo(L-Trp-L-Trp) may inhibit Acinetobacter baumannii (MICs=12.5-25 µg/mL), as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, and Staphylococcus aureus (MICs=12.5) -50 µg/mL)[1].
Cyclo-L-Trp-L-Trp is an antibiotic that shows antimicrobial activity. It inhibits the growth of 41 out of 49 strains of multidrug resistant A. baumannii as well as B. subtilis. It also inhibits Candida albicans, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, and Staphylococcus aureus. |
| ln Vivo |
Cyclo-L-Trp-L-Trp has been used as a substrate for indole prenyltransferases in the synthesis of mono- and diprenylated indolines. It has shown notable inhibitory effects against a spectrum of bacterial and fungal pathogens.
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| Enzyme Assay |
Cyclo-L-Trp-L-Trp is evaluated in cell-free antimicrobial assays. The compound is tested against various bacterial and fungal strains, and minimum inhibitory concentrations are determined.
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| Cell Assay |
Cyclo-L-Trp-L-Trp is assessed in cell-based antimicrobial assays using bacterial and fungal cultures. The compound is tested against various pathogens, and growth inhibition is measured.
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| Animal Protocol |
Cyclo-L-Trp-L-Trp is administered in animal models to evaluate its antimicrobial efficacy. However, specific animal study protocols are not extensively documented.
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| ADME/Pharmacokinetics |
Cyclo-L-Trp-L-Trp has a molecular weight of 372.43 and a molecular formula of C22H20N4O2. It has a CAS number of 20829-55-4. The compound should be stored at 2-8°C in a refrigerator.
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| Toxicity/Toxicokinetics |
No detailed toxicity data is available for Cyclo-L-Trp-L-Trp. The compound is for research use only and is not intended for human therapeutic use.
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| References | |
| Additional Infomation |
Cyclo-(L-Trp-L-Trp) is an organic nitrogen and organic oxygen compound. Functionally, it is associated with α-amino acids. (3S,6S)-3,6-bis((1H-indol-3-yl)methyl)piperazine-2,5-dione has been reported in Penicillium dierckxii, Penicillium simplicissimum, and Penicillium fellutanum, and relevant data are available.
Cyclo-L-Trp-L-Trp is a cyclic dipeptide antibiotic. It has a CAS number of 20829-55-4. It shows antimicrobial activity against a range of bacterial and fungal pathogens. It is not approved for clinical use. |
| Molecular Formula |
C22H20N4O2
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|---|---|
| Molecular Weight |
372.42000
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| Exact Mass |
372.158
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| CAS # |
20829-55-4
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| PubChem CID |
7091706
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
813.4±60.0 °C at 760 mmHg
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| Flash Point |
445.7±32.9 °C
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| Vapour Pressure |
0.0±2.9 mmHg at 25°C
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| Index of Refraction |
1.724
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| LogP |
1.66
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
28
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| Complexity |
559
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C1=CC=C2C(=C1)C(=CN2)C[C@H]3C(=O)N[C@H](C(=O)N3)CC4=CNC5=CC=CC=C54
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| InChi Key |
DNHODRZUCGXYKU-PMACEKPBSA-N
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| InChi Code |
InChI=1S/C22H20N4O2/c27-21-19(9-13-11-23-17-7-3-1-5-15(13)17)25-22(28)20(26-21)10-14-12-24-18-8-4-2-6-16(14)18/h1-8,11-12,19-20,23-24H,9-10H2,(H,25,28)(H,26,27)/t19-,20-/m0/s1
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| Chemical Name |
(3S,6S)-3,6-bis(1H-indol-3-ylmethyl)piperazine-2,5-dione
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~335.64 mM)
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6851 mL | 13.4257 mL | 26.8514 mL | |
| 5 mM | 0.5370 mL | 2.6851 mL | 5.3703 mL | |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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