| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
| Targets |
Cloxyfonac targets auxin receptors and signaling pathways in plants, mimicking the effects of natural auxin hormones. It binds to auxin receptor proteins (TIR1/AFB) and modulates gene expression involved in cell elongation, division, and differentiation.
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|---|---|
| ln Vitro |
Cloxyfonac exhibits auxin-like activity in plants, promoting or inhibiting growth depending on concentration. As a plant growth regulator, it modulates developmental processes including rooting, flowering, and fruit set. Limited data on mammalian biological activity are available.
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| ln Vivo |
In vivo activity of Cloxyfonac is primarily studied in plant systems. In animal models, as a pesticide transformation product, its biological effects are of toxicological interest rather than therapeutic application.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for Cloxyfonac are typically performed in plant systems. Binding to auxin receptor TIR1 can be assessed using radioligand binding or surface plasmon resonance. In mammalian systems, it may be evaluated for endocrine disruption potential using receptor binding assays.
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| Cell Assay |
In vitro cell-based assays for Cloxyfonac are primarily conducted in plant cell cultures to study auxin signaling and growth regulation. In mammalian toxicology studies, cell lines such as hepatocytes or endocrine cells may be used to assess cytotoxicity, genotoxicity, or endocrine-disrupting potential.
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| Animal Protocol |
In vivo animal studies for Cloxyfonac are primarily toxicological, using rodent models to assess acute and chronic toxicity, reproductive effects, and carcinogenic potential following oral or dermal administration. Standard OECD test guidelines are typically followed for pesticide safety evaluation.
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| ADME/Pharmacokinetics |
Cloxyfonac has a molecular weight of 216.62 g/mol and formula C₉H₉ClO₄. It is a small polar molecule with moderate water solubility. As a pesticide, it undergoes environmental degradation and metabolic transformation in plants and animals. Detailed mammalian PK data are limited.
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| Toxicity/Toxicokinetics |
Cloxyfonac is classified as a plant growth regulator with relatively low mammalian toxicity based on its use as a pesticide. However, as with all pesticides, appropriate safety precautions should be taken. Comprehensive toxicological data are available through regulatory submissions for pesticide registration.
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| Additional Infomation |
Cloxyfonac is primarily used in agricultural research as a plant growth regulator and is also studied as a chemical transformation product pesticide. It is not used as a pharmaceutical agent. Also known as [4-chloro-2-(hydroxymethyl)phenoxy]acetic acid and Trylone.
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| Molecular Formula |
C9H9CLO4
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|---|---|
| Molecular Weight |
216.6184
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| Exact Mass |
216.019
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| CAS # |
6386-63-6
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| PubChem CID |
22883
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| Appearance |
White to off-white solid powder
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| Density |
1.44g/cm3
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| Boiling Point |
391.4ºC at 760 mmHg
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| Flash Point |
190.5ºC
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| Index of Refraction |
1.586
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| LogP |
1.295
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
14
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| Complexity |
197
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZJRUTGDCLVIVRD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H9ClO4/c10-7-1-2-8(6(3-7)4-11)14-5-9(12)13/h1-3,11H,4-5H2,(H,12,13)
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| Chemical Name |
2-[4-chloro-2-(hydroxymethyl)phenoxy]acetic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~577.05 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6164 mL | 23.0819 mL | 46.1638 mL | |
| 5 mM | 0.9233 mL | 4.6164 mL | 9.2328 mL | |
| 10 mM | 0.4616 mL | 2.3082 mL | 4.6164 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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