| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
As a synthetic dye, C.I. Acid Orange 20 does not have a specific pharmacological target. Its primary applications are industrial and cosmetic, rather than therapeutic. The compound is used as a colorant and may interact with biological systems through non-specific mechanisms. It has been used as a food dye in some contexts. Further research is needed to identify any specific molecular targets.
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|---|---|
| ln Vitro |
C.I. Acid Orange 20 itself is not known to possess direct therapeutic activity. Its significance is as a synthetic dye for industrial and cosmetic applications. The compound has been used as a food dye. As an azo dye, it may undergo metabolic reduction to aromatic amines, which could have biological effects, but these are not considered therapeutic.
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| ln Vivo |
There is no reported in vivo therapeutic activity for C.I. Acid Orange 20, as it is primarily an industrial and cosmetic colorant rather than a drug candidate. The compound has been used as a food dye. Its role in biological systems is primarily as a coloring agent rather than a pharmacologically active compound.
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| Enzyme Assay |
As a synthetic dye, there are no standardized in vitro enzyme/receptor binding assays for C.I. Acid Orange 20 itself. The compound's utility is in industrial applications such as textile dyeing, paper coloring, and cosmetic colorants. Researchers may study the compound's interactions with biological systems in the context of dye metabolism or toxicity.
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| Cell Assay |
There are no reported in vitro cellular assays for C.I. Acid Orange 20 as a therapeutic agent. The compound is used in industrial and cosmetic applications. Cellular studies may be conducted to assess the compound's toxicity, metabolism, or potential for causing allergic reactions, but these are not therapeutic assays.
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| Animal Protocol |
There are no reported in vivo animal studies for C.I. Acid Orange 20 as a therapeutic agent. The compound is primarily used in industrial and cosmetic applications. Animal studies may be conducted to assess the compound's toxicity, metabolism, or potential for causing allergic reactions, but these are not therapeutic studies.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
In animals without diarrhea, the low excretion of hesperidin I is due to degradation by intestinal flora rather than absorption through the intestinal wall. In dogs with bile fistulas, oral administration of 100 mg of hesperidin I resulted in a bile recovery rate of only 0.4%, while subcutaneous injection showed a recovery rate as high as 47%. Metabolism/Metabolites Forty-eight hours after administering 5 g of hesperidin I to a dog, its urine contained trace amounts of uncolored material, as well as sulfamethoxam and 4-amino-1-naphthol. As a synthetic dye used in industrial and cosmetic applications, there are limited pharmacokinetic data for C.I. Acid Orange 20. The compound has a molecular weight of 350.33 and a logP that influences its distribution. It is soluble in water and may be absorbed through skin or ingestion. Further pharmacokinetic studies are needed. |
| Toxicity/Toxicokinetics |
The toxicological properties of C.I. Acid Orange 20 have not been fully investigated. As an azo dye, it may be metabolized to aromatic amines, some of which are known carcinogens. The compound should be handled with appropriate safety precautions. Toxicological studies would be needed to fully characterize its safety profile for any potential therapeutic or food applications.
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| References | |
| Additional Infomation |
CI Acid Orange 20 is an organic molecular entity.
See also: Benzyl thiocyanate (note moved to). C.I. Acid Orange 20 (Orange I, α-Naphthol Orange) is a synthetic azo dye belonging to the acid dye class, used in textile dyeing, paper coloring, and as a colorant in cosmetic and personal care products. It has also been used as a food dye. The compound is an aromatic sulfonated p-azo dye that interferes with microbial degradation. It is not a therapeutic agent but an industrial colorant. |
| Molecular Formula |
C16H11N2NAO4S
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|---|---|
| Molecular Weight |
350.32
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| Exact Mass |
350.033
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| CAS # |
523-44-4
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| PubChem CID |
135513128
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| Appearance |
Brown to reddish brown solid powder
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| LogP |
4.945
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
3
|
| Heavy Atom Count |
24
|
| Complexity |
529
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
AZLXCBPKSXFMET-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C16H12N2O4S.Na/c19-16-10-9-15(13-3-1-2-4-14(13)16)18-17-11-5-7-12(8-6-11)23(20,21)22;/h1-10,19H,(H,20,21,22);/q;+1/p-1
|
| Chemical Name |
sodium;4-[(4-hydroxynaphthalen-1-yl)diazenyl]benzenesulfonate
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| Synonyms |
Java Orange I; Japan Orange 402; C.I. Acid Orange 20
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8545 mL | 14.2727 mL | 28.5453 mL | |
| 5 mM | 0.5709 mL | 2.8545 mL | 5.7091 mL | |
| 10 mM | 0.2855 mL | 1.4273 mL | 2.8545 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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