| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| Targets |
Chromoionophore I does not have a specific biological target. Its mechanism of action is chemical rather than biological. As a chromoionophore, it is a lipophilic dye that partitions into polymeric membranes (e.g., plasticized PVC membranes) used in optical sensors. The compound undergoes a color change (from yellow to blue or vice versa) upon protonation or deprotonation of its tertiary amine group. This color change is coupled with the ion-exchange or co-extraction of target ions into the membrane, providing a signal that is proportional to the concentration of the target ion in the sample.
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|---|---|
| ln Vitro |
Chromoionophore I exhibits pH-dependent absorbance changes in the visible spectrum. In its deprotonated form, the compound is yellow with an absorbance maximum around 450 nm. Upon protonation, the compound undergoes a color change to blue with an absorbance maximum around 650 nm. The pKa of Chromoionophore I is approximately 8.5-9.5 in typical optode membranes. The compound's absorbance changes are reversible and can be used to measure pH changes in the sample or to detect ions that are co-extracted with protons into the membrane. The compound does not exhibit pharmacological activity.
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| ln Vivo |
Chromoionophore I does not have in vivo pharmacological activity. It is a chemical reagent used for analytical and sensor development applications. The compound is not administered to animals for therapeutic or pharmacological studies. Its use is limited to in vitro and ex vivo applications for the development and characterization of optical chemical sensors.
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| Enzyme Assay |
Non-cellular assays for Chromoionophore I typically involve its use as an ion-selective indicator in optode membranes. In a typical assay, Chromoionophore I is incorporated into a plasticized PVC membrane along with an ionophore (ion carrier) and a lipophilic ion-exchanger. The membrane is placed in contact with an aqueous solution containing the target ion. The absorbance or reflectance of the membrane is measured at the appropriate wavelengths. Changes in absorbance are correlated with the concentration of the target ion in the sample. Calibration curves are prepared using standard solutions of known ion concentrations.
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| Cell Assay |
In vitro cellular assays for Chromoionophore I are not typically conducted, as the compound is used as an analytical reagent rather than a biological tool. The compound may be used in cell-based sensor applications, but such applications are specialized and not standard. Chromoionophore I is primarily used in the development and characterization of optical sensors for ion detection in environmental and clinical samples.
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| Animal Protocol |
Chromoionophore I is not used in in vivo animal studies as a therapeutic or pharmacological agent. Its application in animal research is limited to its use as a sensor component for measuring ion concentrations in biological samples such as blood, plasma, or urine. The compound is not administered to animals for therapeutic purposes.
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| ADME/Pharmacokinetics |
Chromoionophore I is not a drug and does not have pharmacokinetic properties. Its physical and chemical properties are more relevant: it is a lipophilic, neutral chromoionophore with a molecular weight of 528.69 and a molecular formula of C₃₂H₄₀N₄O₃. The compound is soluble in organic solvents such as tetrahydrofuran (THF) and is typically incorporated into polymeric membranes for sensor applications.
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| Toxicity/Toxicokinetics |
Specific toxicological data for Chromoionophore I are not extensively detailed in standard product information. As a research chemical, it should be handled with standard laboratory precautions, avoiding inhalation, ingestion, and skin contact. The compound is not intended for human use. Appropriate personal protective equipment should be worn when handling this compound.
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| References | |
| Additional Infomation |
Chromoionophore I is a research-grade chemical reagent intended for laboratory use only and is not approved for clinical use. Its CAS number is 125829-24-5. The primary applications of Chromoionophore I include the development of ion-selective optical sensors (optodes) for the detection of various ions in environmental monitoring, clinical diagnostics, and analytical chemistry. The compound is also known as ETH 5294. Chromoionophore I is a valuable tool for the study of ion-selective sensing mechanisms and for the development of novel optical sensor technologies.
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| Molecular Formula |
C38H53N3O2
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|---|---|
| Molecular Weight |
583.84632
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| Exact Mass |
583.414
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| CAS # |
125829-24-5
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| PubChem CID |
4403211
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| Appearance |
Brown to black solid powder
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| Density |
1.06 g/cm3
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| Boiling Point |
680.824ºC at 760 mmHg
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| Melting Point |
91-93ºC(lit.)
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| Flash Point |
365.549ºC
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| Index of Refraction |
1.565
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| LogP |
10.62
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
19
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| Heavy Atom Count |
43
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| Complexity |
920
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
MYWBZQJIXVRCJC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C38H53N3O2/c1-4-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25-37(42)39-34-29-36-38(32-24-22-21-23-31(32)34)40-33-27-26-30(28-35(33)43-36)41(5-2)6-3/h21-24,26-29H,4-20,25H2,1-3H3
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| Chemical Name |
N-[9-(diethylamino)benzo[a]phenoxazin-5-ylidene]octadecanamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7128 mL | 8.5638 mL | 17.1277 mL | |
| 5 mM | 0.3426 mL | 1.7128 mL | 3.4255 mL | |
| 10 mM | 0.1713 mL | 0.8564 mL | 1.7128 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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