| Size | Price | |
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| Other Sizes |
| Targets |
Chlorthal-dimethyl acts as a plant growth regulator and herbicide. It causes localized swelling and disrupts mitosis in germinating seedlings. It interferes with cell division and differentiation, affecting the normal development of vascular tissue. Its herbicidal activity is selective, targeting specific weed species while sparing crops.
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| ln Vitro |
In vitro, chlorthal-dimethyl affects cell division and differentiation in plant cell cultures. It causes localized swelling and disrupts mitosis in germinating millet seedlings. It is a plant growth regulator that affects mitosis and cell division.
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| ln Vivo |
In vivo, chlorthal-dimethyl is used for preemergence weed control in turf, ornamentals, strawberries, and agronomic crops including cotton, soybeans, and field beans. It is effective against smooth and hairy crabgrass, witchgrass, green and yellow foxtails, fall panicum, and other annual grasses.
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| Enzyme Assay |
In vitro herbicidal activity is assessed using plant cell cultures or seedling growth assays. Seeds are germinated in agar or soil containing chlorthal-dimethyl at various concentrations. Germination rate, root elongation, and shoot growth are measured. Microscopic analysis assesses mitotic disruption and vascular tissue development.
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| Cell Assay |
Plant cell cultures (e.g., from millet, Arabidopsis, or crop species) or whole seedling assays are used. Cells or seedlings are treated with chlorthal-dimethyl at various concentrations. Cell division is assessed by counting mitotic figures. Vascular tissue development is evaluated by histological staining and microscopy.
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| Animal Protocol |
In vivo herbicidal efficacy is evaluated in greenhouse or field trials. Chlorthal-dimethyl is applied preemergence as a spray or granular formulation. Weed control is assessed by counting weed density, measuring weed biomass, and calculating percent control. Crop safety and yield are also evaluated. Regulatory studies assess environmental fate and toxicity.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Metabolized in animals to monomethyl ester and chloral, and excreted in urine. Metabolic studies in humans and dogs have shown that… ester bond hydrolysis… leads to the excretion of monocarboxylic acid or dicarboxylic acid derivatives in urine. The remainder is excreted unchanged in feces. No significant storage in body tissues has been found. No dacalorie residues were detected in the milk of dairy cows fed this compound feed. Approximately 1% intact dacalorie was detected in feces. Dacaloic acid (2,3,5,6-tetrachloromonomethylterephthalic acid) is primarily excreted via feces (3.3%) and urine (90.9%). …Not absorbed by leaves. …Not transported by plants. …Kills germinating seeds; the exact mechanism is unclear. …Not considered to be metabolized by plants. Metabolism/Metabolites Dacaloic acid (2,3,5,6-tetrachloromonomethylterephthalic acid) is primarily excreted in feces (3.3%) and urine (90.9%). Liver tablets rapidly produce this metabolite. Dacaloic acid does not break down when incubated with rumen contents. Studies in humans and dogs show that ester bonds undergo significant hydrolysis…leading to the excretion of monocarboxylic acid or dicarboxylic acid derivatives in urine. Chlorthal-dimethyl has a molecular formula of C₁₀H₆Cl₄O₄ and a molecular weight of 331.96. It has a melting point of 155-156°C. It is a chlorinated aromatic ester. Environmental persistence and degradation are studied for regulatory purposes. Specific mammalian pharmacokinetic parameters are not extensively documented. |
| Toxicity/Toxicokinetics |
Chlorthal-dimethyl has low acute toxicity in mammals. The US EPA has proposed classification for reproductive toxicity based on studies showing effects on thyroid hormones and reproduction in rats. It is considered a potential endocrine disruptor. Proper protective equipment should be used when handling.
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| Additional Infomation |
Dactal is a diester and methyl ester.
Chlorthal-dimethyl (DCPA, Dacthal) is a preemergence herbicide registered in the US since 1958. It is used for weed control in various crops, turf, and ornamentals. It is subject to regulatory review by the US EPA through the registration review program. Its use is approved in many countries, though regulatory restrictions exist in some regions. |
| Molecular Formula |
C10H6CL4O4
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|---|---|
| Molecular Weight |
331.1
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| Exact Mass |
329.902
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| CAS # |
1861-32-1
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| Related CAS # |
Chlorthal-dimethyl-d6;350818-66-5
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| PubChem CID |
2943
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| Appearance |
CRYSTALS FROM METHANOL
COLORLESS CRYSTALS |
| Density |
1.6±0.1 g/cm3
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| Boiling Point |
422.0±40.0 °C at 760 mmHg
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| Melting Point |
155-156°C
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| Flash Point |
174.7±26.3 °C
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| Vapour Pressure |
0.0±1.0 mmHg at 25°C
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| Index of Refraction |
1.565
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| LogP |
3.48
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
|
| Heavy Atom Count |
18
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| Complexity |
290
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
#479MBsG1LH9FnH7UqkdUvhGg5oxUvhG1LxG1MsF1nH7UqkdFnH9UqkdMfH=
|
| InChi Key |
NPOJQCVWMSKXDN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H6Cl4O4/c1-17-9(15)3-5(11)7(13)4(10(16)18-2)8(14)6(3)12/h1-2H3
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| Chemical Name |
dimethyl 2,3,5,6-tetrachlorobenzene-1,4-dicarboxylate
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| Synonyms |
DCPA; Dacthalor; Chlorthal-dimethy
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~16.67 mg/mL (~50.22 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0202 mL | 15.1012 mL | 30.2024 mL | |
| 5 mM | 0.6040 mL | 3.0202 mL | 6.0405 mL | |
| 10 mM | 0.3020 mL | 1.5101 mL | 3.0202 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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