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Description: Cetrorelix dicetate (SB-75) is a novel, potent and synthetic gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. Cetrorelix acetate is a decapeptide with the potential to be used in infertility treatment. The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ovary. The proliferation of human ovarian cancer cell lines is time- and dose-dependently reduced by GnRH and its superagonistic analogs.
References: Reprod Biol Endocrinol. 2003 Oct 7;1:65;
Related CAS #: 145672-81-7 (mono acetate); 130143-01-0 (2 acetate) 120287-85-6 (free base) 130289-71-3 (3TFA) 165186-69-6 (pamoate)
M.F.: C₇₄H₁₀₀ClN₁₇O₁₈
M.W.: 1551.14
Synonym: SB 075 diacetate; NS-75-A; SB075 diacetate; NS-75 A; Cetrotide; D 20761; D-20761; D20761; NS-75A; NS 75A; SB-075 acetate
Sequence Shortening: Ac-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-SY-{Cit}-LRPA-NH2
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2