| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
Purity: ≥98%
| Targets |
Canthaxanthin does not have a single specific pharmacological target. Its mechanism of action is believed to involve scavenging free radicals and reducing oxidative stress. Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. The compound has shown antioxidant, anti-inflammatory, and anticancer properties.
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| ln Vitro |
Enriching LDL with canthaxanthin may be able to prevent cholesterol from oxidizing. Apart from its ability to scavenge and act as an antioxidant (e.g., by inducing catalase and superoxide dismutase), canthaxanthin also possesses immunomodulatory properties (e.g., by promoting the proliferation and function of cells in an immunocompetent state) and regulates, which is crucial for communication (e.g., by inducing transmembrane proteins connexin) [1]. The total number of tumor cells is dramatically reduced by canthaxanthin at doses ranging from 0.1 to 1 × 1000 μM. After 72 and 96 hours of isolation, maximum inhibition was seen at a canthaxanthin concentration of 1000 [2].
Canthaxanthin exhibits antioxidant activity by scavenging free radicals and reducing oxidative stress. It has been shown to have various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. The compound's antioxidant properties are believed to contribute to its biological effects. |
| ln Vivo |
Canthaxanthin alters the ability of tissues to protect against oxidative stress. After 15 days of canthaxanthin treatment at a dose of 14 μg/kg, carotenoids were added annually to HW, reaching a content of 0.52 ± 0.05 nmol/g. Mice treated with canthaxanthin showed a 35% decrease in glutathione peroxidase activity compared to Manhattan, and a 28% decrease in catalase (59%) and mango superoxide dismutase (28%) activities compared to the dye solution [3]. The dosage of supplements has an impact on both the growth of breast tumors and their anti-tumor activity [4]. Breast cancer incidence is reduced by 65% when canthaxanthin is added to the diet three weeks prior to admission, through a mechanism unrelated to provitamin A activity [5].
In vivo, canthaxanthin has been studied for its antioxidant, anti-inflammatory, and anticancer properties. It is used as a food colorant and in animal feed. Indirect exposure through the use of canthaxanthin as a colorant in animal feeds is the major source of canthaxanthin in food. The compound has been permanently listed by the FDA for use in foods and drugs. |
| Enzyme Assay |
In vitro enzyme assays for canthaxanthin typically involve measuring its antioxidant capacity through free radical scavenging assays such as DPPH, ABTS, or ORAC. The compound's ability to protect LDL from oxidation can be assessed by measuring conjugated diene formation or TBARS. These assays confirm the antioxidant activity of canthaxanthin.
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| Cell Assay |
In vitro cellular assays for canthaxanthin involve treating cells with the compound and measuring oxidative stress markers, cell viability, or inflammatory responses. Cells are treated with various concentrations of canthaxanthin, and reactive oxygen species (ROS) levels are measured using fluorescent probes. The compound's ability to reduce oxidative stress and inflammation is assessed.
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| Animal Protocol |
In vivo animal studies for canthaxanthin typically involve administration to rodents or other species to assess its antioxidant, anti-inflammatory, or anticancer properties. The compound is also studied in the context of animal feed, particularly for salmonid and broiler chicken feed. Efficacy is assessed by measuring oxidative stress markers, inflammatory responses, or tumor burden.
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| ADME/Pharmacokinetics |
Pharmacokinetic studies of canthaxanthin show that the compound is a lipophilic carotenoid that is absorbed from the diet and distributed to various tissues. It has a melting point of approximately 210°C (decomposes). The compound is sensitive to oxygen and light and should be stored in inert gas-filled light-protected containers. It is soluble in chloroform (10%) and slightly soluble in vegetable oil (0.005%).
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| Toxicity/Toxicokinetics |
Preclinical toxicity studies of canthaxanthin have established its safety for use as a food colorant and in animal feed. The compound is permanently listed by the FDA for use in foods and drugs. Restrictions include use in foods generally, not to exceed 30 mg/lb of solid or semisolid food or per pint of liquid food. The compound is also approved for specific uses in animal food.
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| References | |
| Additional Infomation |
Canthaxanthin is a carotenoid ketone composed of β,β-carotene with two oxygen substituents at the 4' and 4' positions, respectively. It is a biopigment, food coloring agent, fungal metabolite, and Escherichia coli metabolite. It is derived from the hydrogenation of β-carotene. Canthaxanthin has been reported in red algae (Planktothrix rubescens), Planktothrix agardhii, and other organisms with relevant data. It is a trans-carotenoid pigment widely distributed in nature. This compound can be used as an oral tanning agent and as a food and pharmaceutical coloring agent. Oral ingestion of this compound can lead to canthaxanthin retinopathy.
Canthaxanthin (C.I. Food Orange 8, E161g) is a red-orange carotenoid pigment with antioxidant, anti-inflammatory, and anticancer properties. It is the carotenoid of most intense red color and is used as a food colorant and in animal feed. The compound is available in oil-soluble, oil-dispersible, and water-dispersible forms. It is permanently listed by the FDA for use in foods and drugs. Its mechanism of action involves scavenging free radicals and reducing oxidative stress. |
| Molecular Formula |
C40H52O2
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|---|---|
| Molecular Weight |
564.84
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| Exact Mass |
564.396
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| CAS # |
514-78-3
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| PubChem CID |
5281227
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| Appearance |
Reddish brown to black solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
717.0±40.0 °C at 760 mmHg
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| Flash Point |
253.9±24.3 °C
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| Vapour Pressure |
0.0±2.3 mmHg at 25°C
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| Index of Refraction |
1.575
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| LogP |
10.69
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
42
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| Complexity |
1270
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC1=C(C(CCC1=O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C(=O)CCC2(C)C)C)\C)\C)/C)/C
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| InChi Key |
FDSDTBUPSURDBL-DKLMTRRASA-N
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| InChi Code |
InChI=1S/C40H52O2/c1-29(17-13-19-31(3)21-23-35-33(5)37(41)25-27-39(35,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-36-34(6)38(42)26-28-40(36,9)10/h11-24H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+
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| Chemical Name |
3,3'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(2,4,4-trimethylcyclohex-2-en-1-one)
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| Synonyms |
CI 40850 E 161 G Ro 1-9915 C.I. Food Orange 8
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. (3). This product is not stable in solution, please use freshly prepared working solution for optimal results. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7704 mL | 8.8521 mL | 17.7041 mL | |
| 5 mM | 0.3541 mL | 1.7704 mL | 3.5408 mL | |
| 10 mM | 0.1770 mL | 0.8852 mL | 1.7704 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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