| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
| Targets |
As an inorganic compound, calcium phosphate dibasic does not have a specific pharmacological target. It is used as a mineral supplement to provide calcium and phosphate for bone health and metabolic functions. The compound is used in food, animal feed, and various industrial applications.
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| ln Vitro |
Calcium phosphate dibasic provides calcium and phosphate ions when dissolved or ingested. These ions are essential for bone mineralization, muscle function, nerve transmission, and various metabolic processes. The compound is used as a dietary supplement to prevent or treat calcium deficiency. It is also used as a flour treatment agent and yeast food.
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| ln Vivo |
In vivo, calcium phosphate dibasic is used as a calcium and phosphate supplement in human food and animal feed. It is also used as a dough conditioner and yeast food. The compound provides essential minerals for bone health and metabolic functions.
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| Enzyme Assay |
As an inorganic compound used primarily as a dietary supplement, there are no standardized in vitro enzyme/receptor binding assays for calcium phosphate dibasic. The compound's utility is in providing calcium and phosphate for nutritional and industrial applications.
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| Cell Assay |
There are no reported in vitro cellular assays for calcium phosphate dibasic as a therapeutic agent. The compound is used as a dietary supplement and in food applications. Cellular studies may be conducted to assess calcium uptake or mineralization, but these are not therapeutic assays.
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| Animal Protocol |
There are no reported in vivo animal studies for calcium phosphate dibasic as a therapeutic agent. The compound is primarily used as a dietary supplement in food and animal feed. Animal studies may be conducted to assess calcium absorption or bone health, but these are nutritional rather than therapeutic studies.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
... Its components are slowly absorbed in the small intestine. Calcium phosphate dibasic is practically insoluble in water but soluble in hydrochloric acid, nitric acid, acetic acid, and ammonium citrate solution. At red heat, it is dehydrated to calcium pyrophosphate. The compound has a molecular weight of 136.06 and a molecular formula of CaHPO4. |
| Toxicity/Toxicokinetics |
Calcium phosphate dibasic is considered safe for its intended uses as a food supplement and additive. It is found in nature as the mineral monetite. The compound is generally recognized as safe (GRAS) for use in food and animal feed. It is used as a food additive with INS number 341(ii).
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| Additional Infomation |
Calcium hydrogen phosphate is a type of calcium phosphate.
Therapeutic Use Uses—An excellent source of calcium and phosphorus during pregnancy, lactation, or mild to moderate hypocalcemia (characterized by mild tetany). …If tetany is severe, intravenous calcium supplementation may be necessary. …Dosage—1 to 5 grams daily, divided into two or more doses. This product is not sold as a single formulation; therefore, the dosage of other components may need to be considered when developing an appropriate dosing regimen.Low doses and frequent administration of calcium are more readily absorbed. Medicinal (Veterinary): Used for the prevention and treatment of rickets, in conjunction with vitamin D therapy, and as a source of calcium and phosphorus in feed. The calcium-to-phosphorus ratio in the diet must be maintained at an optimal level. Calcium hydrogen phosphate, National Formulary…/belongs to CMPD/, is classified as a non-systemic gastric acid inhibitor, but its efficacy is low and it is rarely used. Medicinal (Veterinary): Formerly used as a dietary supplement and antacid. Drug Warning Due to the presence of phosphates, this medication is contraindicated in patients with hypoparathyroidism. Calcium phosphate, dibasic (calcium hydrogen phosphate, dicalcium phosphate) is an inorganic compound with the formula CaHPO4, used as a calcium and phosphate supplement in human food and animal feed, as a dough conditioner, and in dental products, fertilizers, and glass manufacturing. It is a white, odorless, tasteless powder practically insoluble in water and has a molecular weight of 136.06. |
| Molecular Formula |
CAHO4P
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|---|---|
| Molecular Weight |
136.06
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| Exact Mass |
135.923
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| CAS # |
7757-93-9
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| Related CAS # |
10103-46-5 (Parent)
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| PubChem CID |
24441
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| Appearance |
Triclinic crystals
White crystalline powder |
| Density |
2.306（16℃）
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| Boiling Point |
158ºC at 760 mmHg
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
6
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| Complexity |
46.5
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[Ca+2].OP(=O)([O-])[O-]
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| InChi Key |
FUFJGUQYACFECW-UHFFFAOYSA-L
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| InChi Code |
InChI=1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2
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| Chemical Name |
calcium;hydrogen phosphate
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| Synonyms |
Calcium hydrogen phosphate; Calcium hydrogenorthophosphate; Calcium phosphate, dibasic
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: ~1.9 mg/mL (~14.3 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCl and heat to 60°C)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3497 mL | 36.7485 mL | 73.4970 mL | |
| 5 mM | 1.4699 mL | 7.3497 mL | 14.6994 mL | |
| 10 mM | 0.7350 mL | 3.6748 mL | 7.3497 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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