Size | Price | Stock | Qty |
---|---|---|---|
1mg |
|
||
2mg |
|
||
5mg |
|
||
10mg |
|
||
Other Sizes |
|
Purity: ≥98%
BIX-01338 is a novel and potent histone lysine methyltransferase G9a inhibitor with an IC50 value of 4.7µM. BIX01338 was discovered by high-throughput screening along with BIX0129434. Further research reveals that BIX01338 is a SAM (S-adenosylmethionine) inhibitor rather than a substrate competitive inhibitor like BIX01294.
References |
---|
Molecular Formula |
C32H26F3N3O7
|
---|---|
Molecular Weight |
621.559958934784
|
CAS # |
1228184-65-3
|
SMILES |
O=C(C1=CC=C2C(N=C(NC(C3=CC=C(C(F)(F)F)C=C3)=O)N2CCC4=CC=C(OC(C5=CC=C(OC)C=C5)=O)C=C4)=C1)O.O
|
Synonyms |
BIX-01338; BIX01338; BIX 01338
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO : ~200 mg/mL (~321.77 mM)
|
---|
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.6089 mL | 8.0443 mL | 16.0886 mL | |
5 mM | 0.3218 mL | 1.6089 mL | 3.2177 mL | |
10 mM | 0.1609 mL | 0.8044 mL | 1.6089 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.