| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
AFTER ORAL ADMIN OF THERAPEUTIC DOSE OF BEPHENIUM HYDROXYNAPHTHOATE NOT MORE THAN 0.5% IS EXCRETED IN URINE WITHIN 24 HR. /HYDROXYNAPHTHOATE/ NOT ORDINARILY ABSORBED FROM GI TRACT, BUT IF INTESTINES ARE INFLAMED, SOME DRUG MAY BE ABSORBED...EXCRETED IN URINE. /HUMAN, ORAL/ |
|---|---|
| Additional Infomation |
Bephenium is an aromatic amine.
Therapeutic Uses BEPHENIUM HYDROXYNAPHTHOATE IS HIGHLY EFFECTIVE, WHEN GIVEN IN SINGLE DOSE, AGAINST BOTH SPECIES OF HUMAN HOOKWORMS & AGAINST...INFESTATIONS WITH ASCARIS LUMBRICOIDES & TRICHOSTRONGYLUS ORIENTALIS. ...INEFFECTIVE AGAINST STRONGYLOIDES STERCORALIS & HAS...MODERATE ACTIVITY AGAINST TRICHURIS TRICHIURA. /HYDROXYNAPHTHOATE/ BEPHENIUM HYDROXYNAPHTHOATE IS GIVEN ORALLY ON EMPTY STOMACH, & FOOD IS THEN WITHHELD FOR @ LEAST 2 HR. ... /HYDROXYNAPHTHOATE/ MEDICATION (VET): ANTHELMINTIC. /USED/...TO CONTROL & TREAT NEMATODIRUS, OSTERTAGIA, COOPERIA, HEMONCHUS, & TRICHOSTRONGYLUS INFESTATIONS IN CATTLE & SHEEP. /EMBONATE & HYDROXYNAPHTHOATE SALTS/ MEDICATION (VET): ...WIDELY USED FOR PREVENTION & TREATMENT OF NEMATODIRIASIS IN LAMBS... /HYDROXYNAPHTHOATE SALT/ BEPHENIUM EMBONATE IS USED FOR SIMILAR PURPOSES. /EMBONATE SALT/ MEDICATION (VET): TO CONTROL & TREAT...HOOKWORMS IN CATS & DOGS. /HYDROXYNAPHTHOATE SALT/ Drug Warnings DEHYDRATION, ELECTROLYTE IMBALANCE, & DIARRHEA SHOULD BE CORRECTED BEFORE DRUG IS USED. INFORMATION IS LACKING ON SAFETY OF BEPHENIUM DURING PREGNANCY; THEREFORE, POSSIBLE RISK TO FETUS SHOULD BE WEIGHED AGAINST EXPECTED THERAPEUTIC BENEFITS IF THIS AGENT IS CONSIDERED FOR USE IN PREGNANT WOMEN. /HYDROXYNAPHTHOATE SALT/ SIDE EFFECTS ARE USUALLY MINIMAL... DRUG SHOULD BE USED WITH CAUTION IN HYPERTENSIVE PT & OTHERS WITH LABILE BLOOD PRESSURE; IT HAS MILD GANGLIONIC BLOCKING ACTION & IF ABSORBED MIGHT CAUSE BRIEF MARKED FALL IN BLOOD PRESSURE. /HYDROXYNAPHTHOATE SALT/ SPECIAL CAUTION IS INDICATED IF ANTHELMINTICS ARE USED IN PT WITH SEVERE HEPATIC, RENAL, OR CARDIAC DISEASE.../&/ IN CHILDREN UNDER 1 YR OF AGE. /ANTHELMINTICS/ |
| Molecular Formula |
C17H22NO+
|
|---|---|
| Molecular Weight |
256.36268
|
| Exact Mass |
256.169
|
| CAS # |
7181-73-9
|
| Related CAS # |
Bephenium (hydroxynaphthoate);3818-50-6
|
| PubChem CID |
19667
|
| Appearance |
Typically exists as solid at room temperature
|
| Melting Point |
MP: 170-171 °C /HYDROXYNAPHTHOATE/
MP: 144-146 °C /PAMOATE SALT/ MP: 135-136 °C /CHLORIDE SALT/ MP: 144.5-146 °C /BROMIDE SALT/ MP: 146-147 °C /IODIDE SALT/ |
| LogP |
-0.5
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
19
|
| Complexity |
240
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C[N+](CCOC1=CC=CC=C1)(C)CC2=CC=CC=C2
|
| InChi Key |
AVWWVJUMXRXPNF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C17H22NO/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17/h3-12H,13-15H2,1-2H3/q+1
|
| Chemical Name |
benzyl-dimethyl-(2-phenoxyethyl)azanium
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9008 mL | 19.5038 mL | 39.0076 mL | |
| 5 mM | 0.7802 mL | 3.9008 mL | 7.8015 mL | |
| 10 mM | 0.3901 mL | 1.9504 mL | 3.9008 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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