| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
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| Targets |
Atorvastatin Sodium targets HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate in the cholesterol biosynthesis pathway. By inhibiting this enzyme, it reduces the production of cholesterol in the liver. This leads to increased expression of LDL receptors and enhanced clearance of LDL cholesterol from the blood.
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| ln Vitro |
Following myocardial infarction, atorvastatin sodium decreases the expression of GRP78, caspase-12, and CHOP in cardiomyocytes and stimulates the endoplasmic reticulum (ER) in response to angiotensin II (Ang II) stimulation and heart failure. \sup>[4].
In vitro, Atorvastatin Sodium acts as a competitive inhibitor of HMG-CoA reductase. Its inhibitory activity has been characterized in enzyme assays. It also has pleiotropic effects, including anti-inflammatory and antioxidant properties. |
| ln Vivo |
Atorvastatin (20–30 mg/kg; once daily; intracavitary gavage; 28 days; ApoE−/− mice) sodium significantly decreases arthritic cell number, endoplasmic reticulum (ER) protein signaling, and pro-inflammatory cytokines like IL-6, IL-8, and IL-1β were significantly inhibited after treatment with Ang II atorvastatin sodium [5].
In vivo, Atorvastatin Sodium is used for the treatment of hyperlipidemia and the prevention of cardiovascular disease. It effectively lowers LDL cholesterol, triglycerides, and total cholesterol, while increasing HDL cholesterol. |
| Enzyme Assay |
The activity of Atorvastatin Sodium can be assessed using cell-free HMG-CoA reductase enzyme assays. The enzyme is incubated with its substrate, HMG-CoA, and cofactor NADPH in the presence of varying concentrations of the inhibitor. The conversion of HMG-CoA to mevalonate is measured. The IC50 for enzyme inhibition is determined.
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| Cell Assay |
To evaluate the cellular effects of Atorvastatin Sodium, hepatocytes are treated with the compound. The inhibition of cholesterol synthesis and the upregulation of LDL receptors are measured.
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| ADME/Pharmacokinetics |
Atorvastatin Sodium has a molecular formula of C33H34FN2NaO5 and a molecular weight of 580.62 g/mol. Its CAS number is 134523-01-6. It is a white to off-white crystalline powder. It is soluble in water. It should be stored according to the manufacturer's instructions.
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| Toxicity/Toxicokinetics |
Atorvastatin Sodium can cause side effects such as muscle pain, liver enzyme elevation, and gastrointestinal disturbances. It is contraindicated in patients with active liver disease or hypersensitivity to statins. It should be used under medical supervision.
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| References | |
| Additional Infomation |
Atorvastatin sodium is the sodium salt of atorvastatin, a synthetic lipid-lowering drug. Atorvastatin competitively inhibits hepatic hydroxymethylglutaryl-CoA (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Atorvastatin increases the number of low-density lipoprotein (LDL) receptors on the surface of hepatocytes, thereby enhancing LDL uptake and catabolism, reducing LDL production and particle number, and lowering plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also have direct antitumor activity, possibly through inhibiting farnesylation and geranylation of proteins such as small GTP-binding proteins, leading to cell cycle arrest in the G1 phase. The drug may also make tumor cells more sensitive to cell inhibitors, possibly through mTOR-dependent inhibition of Akt phosphorylation.
Atorvastatin Sodium is a statin medication used to lower cholesterol and prevent cardiovascular disease. It is a research tool for studying cholesterol metabolism and cardiovascular disease. |
| Molecular Formula |
C33H34FN2NAO5
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|---|---|
| Molecular Weight |
580.62
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| Exact Mass |
580.234
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| CAS # |
134523-01-6
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| Related CAS # |
134523-03-8 (calcium);344423-98-9 (calcium trihydrate);134523-00-5 (free acid);134523-01-6 (sodium); 874114-41-7 (magnesium);
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| PubChem CID |
23665101
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
722.2±60.0ºC at 760 mmHg
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| Flash Point |
390.6±32.9ºC
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| LogP |
5.051
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
42
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| Complexity |
829
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| Defined Atom Stereocenter Count |
2
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| SMILES |
[Na+].O=C(C[C@@H](C[C@@H](CCN1C(C(C)C)=C(C(NC2=CC=CC=C2)=O)C(C2=CC=CC=C2)=C1C1=CC=C(F)C=C1)O)O)[O-]
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| InChi Key |
VVRPOCPLIUDBSA-CNZCJKERSA-M
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| InChi Code |
InChI=1S/C33H35FN2O5.Na/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;+1/p-1/t26-,27-;/m1./s1
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| Chemical Name |
sodium;(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7223 mL | 8.6115 mL | 17.2230 mL | |
| 5 mM | 0.3445 mL | 1.7223 mL | 3.4446 mL | |
| 10 mM | 0.1722 mL | 0.8611 mL | 1.7223 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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