| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Alginic acid does not have a defined biological target as it is a pharmaceutical excipient rather than a drug. It forms viscous solutions and gels in aqueous media, which can be used for drug delivery, wound healing, and as a thickening agent. Its mechanism of action is physical rather than pharmacological.
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|---|---|
| ln Vitro |
Brown algae can yield alginic acid (AA), a polymer that is frequently used in the food sector [2].
Alginic acid is not a bioactive compound with defined pharmacological activity. Its in vitro activity is related to its physical properties, such as its ability to form gels and viscous solutions. The compound is used as a thickening agent, stabilizer, and gelling agent in various pharmaceutical and food products. |
| ln Vivo |
Alginic acid is not a therapeutic agent and does not have defined in vivo pharmacological activity. It is used as a pharmaceutical excipient for drug delivery, wound healing, and as a thickening agent. The compound is generally recognized as safe and is used in various food and pharmaceutical products.
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| Enzyme Assay |
In vitro assays for Alginic acid typically involve measuring its physical properties such as viscosity, gel strength, and water-binding capacity. The compound is dissolved or dispersed in aqueous media, and rheological properties are measured using viscometers or rheometers. Drug release studies may be performed using alginate-based formulations.
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| Cell Assay |
Cell-based assays are not typically performed with Alginic acid as it is an excipient rather than a bioactive compound. However, its biocompatibility can be assessed by culturing cells in the presence of alginate and measuring cell viability using standard assays. The compound is generally considered biocompatible and non-toxic.
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| Animal Protocol |
In vivo animal studies for Alginic acid are typically conducted as part of safety evaluations for pharmaceutical excipients. The compound is administered orally or via other routes, and parameters such as absorption, distribution, metabolism, and excretion are assessed. The compound is generally well-tolerated and has low toxicity.
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| ADME/Pharmacokinetics |
Alginic acid is a natural polysaccharide with a molecular weight ranging from 10,000 to 600,000. It is a white to yellowish powder that is insoluble in water but forms viscous colloidal solutions when neutralized with alkali. The compound is stable under normal storage conditions. It is used as a pharmaceutical excipient and food additive.
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| Toxicity/Toxicokinetics |
Alginic acid is generally recognized as safe and is used as a pharmaceutical excipient and food additive. It has low toxicity and is well-tolerated. The compound is not associated with significant adverse effects at recommended concentrations. It is not intended for use as a therapeutic agent.
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| References |
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| Additional Infomation |
Alginic acid is a natural polysaccharide extracted from brown seaweed, used as a pharmaceutical excipient, thickener, and gelling agent. It is a linear copolymer of β-D-mannuronic acid and α-L-guluronic acid. The compound is generally recognized as safe and is used in various food and pharmaceutical products. It is not a therapeutic agent.
|
| Molecular Formula |
C14H22O12
|
|---|---|
| Molecular Weight |
382.31728
|
| Exact Mass |
194.042
|
| CAS # |
9005-32-7
|
| Appearance |
White to off-white solid powder
|
| Density |
2.0±0.1 g/cm3
|
| Boiling Point |
495.2±45.0 °C at 760 mmHg
|
| Melting Point |
300 °C
|
| Flash Point |
211.1±22.2 °C
|
| Vapour Pressure |
0.0±2.9 mmHg at 25°C
|
| Index of Refraction |
1.685
|
| LogP |
-2.88
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~3.03 mg/mL (~5.55 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6156 mL | 13.0780 mL | 26.1561 mL | |
| 5 mM | 0.5231 mL | 2.6156 mL | 5.2312 mL | |
| 10 mM | 0.2616 mL | 1.3078 mL | 2.6156 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT01396304 | Terminated | Device: Restore Calcium Alginate Dressing
Device: AquaCel Ag Wound Dressing |
Infection Venous Ulcer |
Hollister Wound Care LLC | 2011-10 | Phase 4 |
| NCT01918410 | Completed | Device: Contact Lens with alginic acid Device: Contact Lens without alginic acid |
Dry Eyes | Louis Tong | 2014-02 | Not Applicable |
| NCT04740086 | Completed | Procedure: Calcium alginate hydrogel | Anal Fistula | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 2016-01-01 | |
| NCT04383262 | Not yet recruiting | Drug: Fosamprenavir Calcium Other: Placebo |
Laryngopharyngeal Reflux | Medical College of Wisconsin | 2024-11-01 | Phase 2 |
| NCT05690685 | Recruiting | Device: Silver I Alginate Non-Woven Dressing (Hydro-Alginate) |
Wound | Advanced Medical Solutions Ltd. | 2023-05-16 | Not Applicable |
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