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    ALG1001 TFA
    ALG1001 TFA

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0433
    CAS #: 1307293-62-4Purity ≥98%

    Description: ALG1001 has been discontinued due to commercial reasons. ALG1001 TFA, the trifluoroacetic acid salt of ALG1001 (also known as Luminate, developed by Allegro Ophthalmics), is small peptide that acts as an inhibitor of angiogenesis and a modulator of integrin α2ß1, αV-ß 3, αV-ß 5. ALG-1001 is a first-in-class integrin peptide therapy which met the primary endpoint of vision non-inferiority to bevacizumab, an anti-vascular endothelial growth factor therapy (anti-VEGF), with 12-week durability in a population of patients with mostly chronic diabetic macular edema (DME). ALG1001's potency relies on anti-angiogenesis and vitreolysis to induce posterior vitreous detachment as well as vitreous liquefaction. ALG1001 was shown to be effective at regressing and inhibiting new blood vessel formation, as well as reducing vascular leakage to maintain and restore vision. ALG-1001 seems to be a strong player with different mechanisms of action that benefit patients who have been receiving chronic anti-VEGF therapy and those who are treatment naïve. 

    References: US 20130129621 A1 20130523; WO 2012154894 A2 20121115.


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    Molecular Weight (MW) 751.68
    Formula C22H39N9O11S TFA
    CAS No. 1307293-62-4 (free base)
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: >10 mM
    Water: >10 mM
    Ethanol: 
    Chemical Name L-Proline, glycyl-L-arginylglycyl-3-sulfo-L-alanyl-L-threonyl- Trifluoroacetic acid
    Synonyms Luminate; H-Gly-Arg-Gly-(L-Ala(SO3))-Thr-Pro-OH; ALG1001; ALG-1001; ALG 1001
    SMILES Code O=C(O)[[email protected]]1N(C([[email protected]]([[email protected]](O)C)NC([[email protected]](CS(=O)(O)=O)NC(CNC([[email protected]](CCCNC(N)=N)NC(CN) =O)=O)=O)=O)=O)CCC1.O=C(O)C(F)(F)F


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    In Vitro

    In vitro activity: ALG1001 (also known as Luminate, developed by Allegro Ophthalmics) is small peptide that acts as an inhibitor of angiogenesis and a modulator of integrin α2ß1, αV-ß 3, αV-ß 5. ALG-1001 is a first-in-class integrin peptide therapy which met the primary endpoint of vision non-inferiority to bevacizumab, an anti-vascular endothelial growth factor therapy (anti-VEGF), with 12-week durability in a population of patients with mostly chronic diabetic macular edema (DME). ALG1001's potency relies on anti-angiogenesis and vitreolysis to induce posterior vitreous detachment as well as vitreous liquefaction. ALG1001 was shown to be effective at regressing and inhibiting new blood vessel formation, as well as reducing vascular leakage to maintain and restore vision. ALG-1001 seems to be a strong player with different mechanisms of action that benefit patients who have been receiving chronic anti-VEGF therapy and those who are treatment naïve.


    Kinase Assay: ALG-1001 binds to the retinal pigment epithelium for several months.


    Cell Assay: ALG-1001 reduced vascular leakage. Other investigations have shown that the formulation affects only stressed retinal cells and has an anti-inflammatory effect,

    In VivoALG-1001 appeared to have 4 times more anti-angiogenic activity compared with aflibercept (Eylea, Regeneron Pharmaceuticals) in a murine model of retinopathy of prematurity.
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    Formulation & Dosage
    References US 20130129621 A1 20130523; WO 2012154894 A2 20121115.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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