| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| Other Sizes |
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| ln Vitro |
The irreversible deamination of adenosine and 2'-deoxyadenosine to produce adenosine deaminase and 2'-deoxyadenosine, respectively, is catalyzed by adenosine deaminase (RnADA). The majority of transcriptional tissues have adenosine deaminase (RnADA), which is connected to adenosine phosphate. Acne loss and severe combined immunodeficiency are the results of hereditary adenosine deaminase deficiency, which lowers acne keratinization and maturation [1]. As a signaling molecule linked to T-pox activation, adenosine deaminase (RnADA) is a useful critical marker, particularly in cases of meningitis and tuberculous pleurisy [2]. Based on stable recombinant protein, this product is stable at pH 7.0–9.0 and 42 KDa (SDS–PAGE). To produce the solution, just reconstitute it with pure water that has been mixed with 20% glycerin, aliquot it based on the prescribed dosage, and store it in the freezer at -20°C. If it is not repeatedly frozen and thawed, it can be stored for two years.
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| References |
[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.
[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823. |
| Additional Infomation |
An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.
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| Molecular Formula |
232-817-5
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|---|---|
| Molecular Weight |
号MFCD00081287
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| Exact Mass |
1335.227
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| CAS # |
9026-93-1
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| PubChem CID |
168009909
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
35.9
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
82
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| Heavy Atom Count |
93
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| Complexity |
1570
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
XKSKQIORVXERAQ-UHFFFAOYSA-O
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| InChi Code |
InChI=1S/C83H164NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-37-38-39-40-41-42-43-44-45-46-48-49-51-53-55-57-59-61-63-65-67-69-71-73-75-82(85)89-79-81(80-91-93(87,88)90-78-77-84(3,4)5)92-83(86)76-74-72-70-68-66-64-62-60-58-56-54-52-50-47-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h25,27,81H,6-24,26,28-80H2,1-5H3/p+1
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| Chemical Name |
2-[(2-dotriacont-21-enoyloxy-3-tritetracontanoyloxypropoxy)-hydroxyphosphoryl]oxyethyl-trimethylazanium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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