| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
ADCI targets two types of ion channels: voltage-activated sodium channels and N-methyl-D-aspartate (NMDA) receptors. It acts as an inhibitor of both, blocking sodium currents and NMDA receptor-mediated currents. This dual-target profile distinguishes it from pure NMDA antagonists and pure sodium channel blockers.
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|---|---|
| ln Vitro |
In vitro, ADCI inhibits voltage-activated sodium channels and NMDA-receptor-gated channels. It has a Ki of approximately 11 µM for NMDA and an IC50 of approximately 14 µM for sodium channels. Its activity is measured in electrophysiological assays.
|
| ln Vivo |
In vivo, ADCI is a broad-spectrum anticonvulsant agent. High doses increase dopamine metabolism in the prefrontal cortex and nucleus accumbens. It is studied for the potential treatment of epilepsy.
|
| Enzyme Assay |
The in vitro receptor binding assay for ADCI involves measuring its inhibition of radiolabeled ligand binding to NMDA receptors, such as [3H]-MK-801 binding. Its effect on sodium channels is measured using electrophysiological techniques or radiolabeled sodium channel toxin binding assays.
|
| Cell Assay |
Cellular in vitro experiments for ADCI are conducted using neurons or cells expressing NMDA receptors or sodium channels. The compound's ability to inhibit NMDA-induced currents or sodium currents is measured using patch-clamp electrophysiology.
|
| Animal Protocol |
In vivo animal experiments for ADCI are performed using models of epilepsy, such as the maximal electroshock seizure (MES) test or the pentylenetetrazole (PTZ) seizure model in mice. The compound's ability to prevent seizures is assessed. Its effects on neurotransmitter levels in the brain are also measured.
|
| References |
| Molecular Formula |
C16H14N2O
|
|---|---|
| Molecular Weight |
250.301
|
| Exact Mass |
250.111
|
| CAS # |
124070-15-1
|
| PubChem CID |
130099
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.305g/cm3
|
| Boiling Point |
460.1ºC at 760mmHg
|
| Flash Point |
232ºC
|
| Vapour Pressure |
1.2E-08mmHg at 25°C
|
| Index of Refraction |
1.679
|
| LogP |
3.094
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
19
|
| Complexity |
396
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC=C2C3(NC(CC2=C1)C1=CC=CC=C31)C(=O)N
|
| InChi Key |
IFLVGRRVGPXYON-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H14N2O/c17-15(19)16-12-7-3-1-5-10(12)9-14(18-16)11-6-2-4-8-13(11)16/h1-8,14,18H,9H2,(H2,17,19)
|
| Chemical Name |
16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene-1-carboxamide
|
| Synonyms |
ADCI SGB017 SGB-017SGB 017
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9952 mL | 19.9760 mL | 39.9521 mL | |
| 5 mM | 0.7990 mL | 3.9952 mL | 7.9904 mL | |
| 10 mM | 0.3995 mL | 1.9976 mL | 3.9952 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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