| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
The specific molecular target of AD 8717 is not detailed in the provided search results. As an inhibitor, it interacts with specific molecular targets and pathways. The compound's mechanism of action involves binding to target proteins and modulating their activity, but the exact target remains unconfirmed.
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|---|---|
| ln Vitro |
In vitro activity data for AD 8717 are not provided. As a bioactive compound, it may be used in assays to study its effects on various cellular or enzymatic systems. However, specific parameters like IC50 or EC50 for any target are not available from the current information.
|
| ln Vivo |
In vivo activity data for AD 8717 are not provided in the search results. Its biological effects in living organisms have not been detailed, and it is primarily used as a research tool in in vitro settings. Further studies would be needed to characterize its in vivo pharmacological profile.
|
| Enzyme Assay |
The in vitro assay for AD 8717 would depend on its specific biological activity, which is not defined. As an inhibitor, it could be used in enzyme inhibition studies or receptor binding assays. The protocol would involve incubating the compound with the target enzyme or receptor and measuring its effect, but specific details are not available.
|
| Cell Assay |
Cellular in vitro experiments for AD 8717 are not detailed. It may be used to study cell signaling or proliferation. Typically, cells would be treated with the compound, and various endpoints such as cell viability, apoptosis, or protein expression would be measured.
|
| Animal Protocol |
In vivo animal experiments for AD 8717 are not described in the search results. It is a research chemical with no reported animal model studies in the provided data. Its use is likely limited to in vitro or ex vivo applications.
|
| Molecular Formula |
C22H19CL2N5O
|
|---|---|
| Molecular Weight |
450.41
|
| Exact Mass |
425.141
|
| CAS # |
181821-99-8
|
| PubChem CID |
177362
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.33g/cm3
|
| Boiling Point |
584.9ºC at 760mmHg
|
| Flash Point |
307.6ºC
|
| Vapour Pressure |
1.14E-13mmHg at 25°C
|
| Index of Refraction |
1.647
|
| LogP |
3.958
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
30
|
| Complexity |
583
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC1=CC(=CC(=N1)C)NC(=O)C2=C(N=CC=C2)S(=O)CC3=C(C=C(C=C3)OC)OC
|
| InChi Key |
PKZCOQYQGMAVLN-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C22H23N3O4S/c1-14-10-17(11-15(2)24-14)25-21(26)19-6-5-9-23-22(19)30(27)13-16-7-8-18(28-3)12-20(16)29-4/h5-12H,13H2,1-4H3,(H,24,25,26)
|
| Chemical Name |
2-[(2,4-dimethoxyphenyl)methylsulfinyl]-N-(2,6-dimethylpyridin-4-yl)pyridine-3-carboxamide
|
| Synonyms |
AD-8717 AD8717 AD 8717
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
|---|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2202 mL | 11.1010 mL | 22.2020 mL | |
| 5 mM | 0.4440 mL | 2.2202 mL | 4.4404 mL | |
| 10 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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