| Size | Price | |
|---|---|---|
| 100mg | ||
| 250mg | ||
| 500mg |
| ln Vitro |
The neurotoxicity caused by amyloid beta protein (Aβ) is inhibited by AC 187. Prior to being exposed to Aβ, treating cultures with AC 187 greatly improves neuronal survival [1]. The activation of promoter and effector caspases that drive Aβ-induced apoptosis is attenuated by AC187 [1].
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|---|---|
| ln Vivo |
In Sprague-Dawley (HSD) rats in a hyperinsulinemic clamp, AC 187 (30 mg/mL) raises glucagon concentrations, speeds up gastric emptying of fluid, and results in postchallenge hyperglycemia [2].
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| References |
[1]. Jack H Jhamandas, et al. Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84.
[2]. Bronislava R Gedulin, et al. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul Pept. 2006 Dec 10;137(3):121-7. |
| Molecular Formula |
C127H205N37O40
|
|---|---|
| Molecular Weight |
2890.21000
|
| CAS # |
151804-77-2
|
| Related CAS # |
AC 187 TFA
|
| SMILES |
NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(=O)N)=O)[C@H](O)C)=O)CC(=O)N)=O)CO)=O)=O)[C@H](O)C)=O)CC(=O)N)=O)[C@H](O)C)=O)CCCNC(=N)N)=O)=O)CC1=CC=C(O)C=C1)=O)[C@H](O)C)=O)CCC(=O)N)=O)CC(C)C)=O)CCCCN)=O)CC1=CN=CN1)=O)CC(C)C)=O)CCC(=O)O)=O)CCC(=O)N)=O)CO)=O)CC(C)C)=O)NC(CNC([C@@H](NC([C@H](C(C)C)NC(=O)C)=O)CC(C)C)=O)=O
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.3460 mL | 1.7300 mL | 3.4600 mL | |
| 5 mM | 0.0692 mL | 0.3460 mL | 0.6920 mL | |
| 10 mM | 0.0346 mL | 0.1730 mL | 0.3460 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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