| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vivo |
Mice treated with acetylphenazine (2.4 mg/kg; ih; single dose) showed a substantial prolongation of both the time from actual fight to submission and the time from first fight to submission [3].
|
|---|---|
| Animal Protocol |
Animal/Disease Models: C57BL mice (10-12 weeks) [3]
Doses: 2.4 mg/kg Route of Administration: ih; Single dose effect: Dramatically prolongs the time from first fight to submission and the time from actual fight to submission. |
| References | |
| Additional Infomation |
Acetylphenazine belongs to the phenothiazine class of compounds, with the structure 10H-phenothiazine, where the nitrogen atom is substituted with a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group and the 2-position is substituted with an acetyl group. It is a phenothiazine antipsychotic drug. Acetylphenazine belongs to the phenothiazine, N-alkylpiperazine, and N-(2-hydroxyethyl)piperazine classes, and its function is related to that of 10H-phenothiazine compounds. Acetylphenazine is a moderately potent antipsychotic drug used to treat confusion and psychotic symptoms, and can also be used as an adjunct treatment for illusions (such as hallucinations or delusions). It primarily acts on dopamine D2 receptors. Drug Indications Used to treat confusion and psychotic symptoms. Also used to help treat delusions (such as hallucinations or delusions). Mechanism of Action Acetylbenzamine blocks postsynaptic mesolimbic dopamine D1 and D2 receptors in the brain; it inhibits the release of hypothalamic and pituitary hormones and is believed to inhibit the reticular activating system, thereby affecting basal metabolism, body temperature, arousal, vasomotor activity, and vomiting. Pharmacodynamics Acetylbenzamine is a phenothiazine antipsychotic drug used to treat schizophrenia and other psychotic disorders.
|
| Molecular Formula |
C23H29N3O2S
|
|---|---|
| Molecular Weight |
411.56026
|
| Exact Mass |
411.198
|
| CAS # |
2751-68-0
|
| Related CAS # |
Acetophenazine-d4 dimaleate
|
| PubChem CID |
17676
|
| Appearance |
Typically exists as solid at room temperature
|
| Density |
1.203g/cm3
|
| Boiling Point |
608.7ºC at 760mmHg
|
| Melting Point |
167-168.5
|
| Flash Point |
321.9ºC
|
| Vapour Pressure |
7.83E-16mmHg at 25°C
|
| Index of Refraction |
1.615
|
| LogP |
3.432
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
7
|
| Heavy Atom Count |
29
|
| Complexity |
540
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
OCCN1CCN(CCCN2C3=C(C=CC(C(=O)C)=C3)SC3C2=CC=CC=3)CC1
|
| InChi Key |
WNTYBHLDCKXEOT-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3
|
| Chemical Name |
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone
|
| Synonyms |
AcetophenazineTindal Acephenazinum
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4298 mL | 12.1489 mL | 24.2978 mL | |
| 5 mM | 0.4860 mL | 2.4298 mL | 4.8596 mL | |
| 10 mM | 0.2430 mL | 1.2149 mL | 2.4298 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT05846438 | Recruiting | Other: Showering 48 hours after surgery |
Infections Quality of Life |
University of Missouri-Columbia | March 15, 2023 | Not Applicable |
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