Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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Targets |
p2X7/AdipoR1 receptor[1]
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ln Vitro |
Zeaxanthin dipalmitate (1 µM; 2 h) completely or partially reverses the ethanol (250 mM)-induced up-regulation of p62 and the down-regulation of Atg5, beclin-1, and LC3A/B in BRL-3A cells[1]. In BRL-3A cells, zeaxanthin dipalmitate (1 µM; 2 h) partially restores the ethanol-suppressed LC3B[1]. BRL-3A cells' ethanol-suppressed cell viability and ethanol-induced aspase -3/7 activity are partially restored by zeaxanthin dipalmitate (1 µM; 2 h)[1]. In BRL-3A cells, the ethanol-induced suppression of mitophagy is recovered by zeaxanthin dipalmitate (1 µM; 2 h)[1].
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ln Vivo |
In an AFLD model, zeaxanthin dipalmitate (10 mg/kg; po; daily for 2 weeks) lowers the serum ALT and AST levels elevated by a prolonged ethanol challenge[1]. Effectively reducing the histological damage is zeaxanthin dipalmitate (10 mg/kg; po; daily for 2 weeks)[1]. Rats treated with zeaxanthin dipalmitate (10 mg/kg; po; daily for 2 weeks) exhibit reduced liver inflammation (TNF-α) and apoptosis (asserted by caspase-3/7 activity) in response to AFLD[1]. Retinal photoreceptor degradation is postponed and the visual behavior of rd10 mice is improved with an intravitreal injection of zeaxanthin dipalmitate (about 4 μM)[2]. The light responses of photoreceptors, bipolar cells, and retinal ganglion cells are enhanced by zeaxanthin dipalmitate (about 4 μM; intravitreal injection for once)[2]. For once, intravitreal injection of zeaxanthin dipalmitate (about 4 μM) lowers the expression of genes linked to oxidative stress, apoptosis, and inflammation in rd10 mice[2].
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References |
[1]. Gao H, et al. Wolfberry-Derived Zeaxanthin Dipalmitate Attenuates Ethanol-Induced Hepatic Damage. Mol Nutr Food Res. 2019 Jun;63(11):e1801339.
[2]. Liu F, et al. Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways. J Neurochem. 2021 Sep;158(5):1131-1150. |
Molecular Formula |
C72H116O4
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Molecular Weight |
1045.69
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CAS # |
144-67-2
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SMILES |
CCCCCCCCCCCCCCCC(OC1CC(C)=C(/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C)CC(OC(CCCCCCCCCCCCCCC)=O)CC2(C)C)\C)\C)/C)/C)C(C)(C)C1)=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80: Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 :Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400  (Please use freshly prepared in vivo formulations for optimal results.) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.9563 mL | 4.7815 mL | 9.5631 mL | |
5 mM | 0.1913 mL | 0.9563 mL | 1.9126 mL | |
10 mM | 0.0956 mL | 0.4782 mL | 0.9563 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.