| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
(±)-Taxifolin targets multiple enzymes and pathways. It exhibits anti-tyrosinase activity and inhibits collagenase with an IC50 of 193.3 μM. The compound is a free radical scavenger with antioxidant capacity. It also has antifibrotic activity. As a flavonoid, it may interact with various signaling pathways involved in inflammation, fibrosis, and oxidative stress.
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| ln Vitro |
In cell-free biochemical systems, (±)-Taxifolin scavenges free radicals such as DPPH. It exhibits antioxidant capacity. The compound inhibits collagenase with an IC50 of 193.3 μM. It also exhibits anti-tyrosinase activity. These activities demonstrate the compound's direct effects on enzymes and free radicals in cell-free systems.
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| ln Vivo |
In cell-based assays, (±)-Taxifolin exhibits antioxidant, anti-tyrosinase, and antifibrotic activities. The compound's effects are evaluated in various cell lines, including fibroblasts and melanocytes. It can protect cells from oxidative stress and inhibit collagen production. The compound's diverse biological activities make it a valuable tool for studying various diseases.
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| Enzyme Assay |
The cell-free assay for antioxidant activity involves measuring the compound's ability to scavenge free radicals such as DPPH (2,2-diphenyl-1-picrylhydrazyl) or ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)). The anti-tyrosinase activity is measured using a spectrophotometric assay with tyrosinase enzyme and L-DOPA as substrate. The collagenase inhibition assay uses purified collagenase and a fluorescent or colorimetric substrate.
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| Cell Assay |
Cell-based assays for (±)-Taxifolin involve culturing relevant cell lines and treating them with the compound at concentrations ranging from 0.1 to 1000 μM. Antioxidant activity is assessed by measuring the compound's ability to protect cells from oxidative stress induced by H2O2 or other oxidants. Anti-tyrosinase activity is evaluated in melanocytes by measuring melanin production. Antifibrotic activity is assessed in fibroblasts by measuring collagen production.
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| Animal Protocol |
There is no established animal experimental protocol for (±)-Taxifolin specifically. As an antioxidant and antifibrotic compound, it could potentially be evaluated in animal models of fibrosis, oxidative stress, and skin diseases. Typical studies involve administration of the compound to mice via oral or intraperitoneal routes. Tissue damage, oxidative stress markers, and fibrosis are assessed.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of (±)-Taxifolin have not been extensively reported. As a small molecule with a molecular weight of 304.25 g/mol, the compound would be expected to have moderate oral bioavailability and tissue penetration. The compound is a flavonoid and may have limited solubility in aqueous solutions. Further pharmacokinetic studies would be required to determine plasma half-life, clearance, and metabolic pathways.
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| Toxicity/Toxicokinetics |
(±)-Taxifolin is intended for research use only and lacks established toxicity profiles for therapeutic applications. Standard laboratory safety precautions should be observed when handling this natural product. As a flavonoid with diverse biological activities, it may have effects on various cellular processes. Standard toxicity studies in rodents would be required to determine the safety profile.
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| References |
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| Additional Infomation |
(+)-taxifolin is a taxifolin with a (2R,3R) configuration. It is a metabolite, the conjugate acid of (+)-taxifolin (1-), and the enantiomer of (-)-taxifolin. taxifolin has been reported in camellia (Camellia reticulata), Japanese birch (Betula platyphylla var. japonica), and other organisms with relevant data. See also: milk thistle (partial); sea pine (partial).
(±)-Taxifolin is a research-grade natural product supplied for antioxidant, anti-tyrosinase, and antifibrotic research. It is not an approved pharmaceutical and has no clinical trial history. The compound is the racemate of Taxifolin, a flavonoid found in various plants. It is a free radical scavenger with antioxidant capacity. This product is intended for research use only. |
| Molecular Formula |
C15H12O7
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|---|---|
| Molecular Weight |
304.25
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| Exact Mass |
304.058
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| CAS # |
24198-97-8
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| Related CAS # |
Taxifolin;480-18-2;(-)-Taxifolin;111003-33-9
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| PubChem CID |
439533
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| Appearance |
White to off-white solid powder
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| Density |
1.7±0.1 g/cm3
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| Boiling Point |
687.6±55.0 °C at 760 mmHg
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| Melting Point |
239-240ºC
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| Flash Point |
264.2±25.0 °C
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| Vapour Pressure |
0.0±2.3 mmHg at 25°C
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| Index of Refraction |
1.763
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| LogP |
1.82
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| Hydrogen Bond Donor Count |
5
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| Hydrogen Bond Acceptor Count |
7
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
22
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| Complexity |
428
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C1=CC(=C(C=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
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| InChi Key |
CXQWRCVTCMQVQX-LSDHHAIUSA-N
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| InChi Code |
InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
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| Chemical Name |
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2868 mL | 16.4339 mL | 32.8677 mL | |
| 5 mM | 0.6574 mL | 3.2868 mL | 6.5735 mL | |
| 10 mM | 0.3287 mL | 1.6434 mL | 3.2868 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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