| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
TP-4748 is not a direct drug target but rather a synthetic building block and biochemical reagent. It has been used in the synthesis of prolyl-tRNA synthase inhibitors. The compound's boronic acid functionality makes it useful for Suzuki-Miyaura cross-coupling reactions in medicinal chemistry. As a heteroaromatic boronic acid, it serves as a versatile intermediate for the construction of more complex molecules.
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| ln Vitro |
TP-4748 is a biochemical reagent with limited direct biological activity reported. Its primary utility is as a synthetic intermediate rather than as a biologically active compound. It is used in the synthesis of prolyl-tRNA synthase inhibitors, which may have biological activity, but TP-4748 itself is not the active pharmaceutical ingredient.
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| ln Vivo |
In vivo activity of TP-4748 has not been reported, as the compound is a synthetic building block rather than a therapeutic agent. It is used in laboratory research for chemical synthesis and is not intended for in vivo studies as a drug candidate. Its utility lies in its role as a precursor for the synthesis of biologically active molecules.
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| Enzyme Assay |
TP-4748 is used as a reagent in Suzuki-Miyaura cross-coupling reactions. The boronic acid functionality reacts with aryl halides in the presence of a palladium catalyst to form carbon-carbon bonds. Reactions are typically performed in organic solvents such as DMF or dioxane with a base (e.g., potassium carbonate) at elevated temperatures. The compound's purity and identity are confirmed by NMR and mass spectrometry.
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| Cell Assay |
Cellular activity of TP-4748 is not typically evaluated, as the compound is a synthetic building block rather than a biologically active agent. It is used in medicinal chemistry for the synthesis of compounds that may subsequently be tested in cellular assays. As a boronic acid, it may have limited cellular permeability and is not intended for direct biological testing.
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| Animal Protocol |
In vivo studies are not applicable to TP-4748 as it is a synthetic building block for laboratory research. The compound is used in chemical synthesis rather than in animal studies. Its role is to enable the preparation of more complex molecules for drug discovery research.
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| ADME/Pharmacokinetics |
TP-4748 has a molecular formula of C7H9BO5 and a molecular weight of 183.95. It is soluble in DMF (30 mg/mL), DMSO (30 mg/mL), and ethanol (1 mg/mL), with limited solubility in aqueous buffers. The compound is stored as powder at -20°C for long-term stability. It appears as a white to off-white powder. Its boronic acid functionality makes it moisture-sensitive and it should be handled under anhydrous conditions.
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| Toxicity/Toxicokinetics |
Toxicological data for TP-4748 are limited, as the compound is a synthetic building block for research use. It is not intended for human or veterinary use. Standard laboratory safety precautions should be followed when handling the compound. Comprehensive toxicology profiling is not applicable as the compound is not a drug candidate.
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| Additional Infomation |
TP-4748 is also known as (2-(ethoxycarbonyl)furan-3-yl)boronic acid or 2-(ethoxycarbonyl)furan-3-boronic acid. It is a heterocyclic building block used in the synthesis of prolyl-tRNA synthase inhibitors. The compound's furan ring with ethoxycarbonyl and boronic acid substituents makes it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions. It supports medicinal chemistry research and drug discovery efforts.
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| Molecular Formula |
C7H9BO5
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|---|---|
| Molecular Weight |
183.954
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| Exact Mass |
184.054
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| Elemental Analysis |
C, 45.71; H, 4.93; B, 5.88; O, 43.49
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| CAS # |
1150114-62-7
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| PubChem CID |
46739469
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| Appearance |
Solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
364.0±52.0 °C at 760 mmHg
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| Flash Point |
173.9±30.7 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.497
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| LogP |
0.89
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
13
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| Complexity |
184
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C([H])=C([H])C(B(O[H])O[H])=C1C(=O)OC([H])([H])C([H])([H])[H]
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| InChi Key |
HKNNWKBXXSBMED-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H9BO5/c1-2-12-7(9)6-5(8(10)11)3-4-13-6/h3-4,10-11H,2H2,1H3
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| Chemical Name |
2-(Ethoxycarbonyl)furan-3-boronic acid
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| Synonyms |
TP-4748; TP 4748; TP4748;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4363 mL | 27.1813 mL | 54.3626 mL | |
| 5 mM | 1.0873 mL | 5.4363 mL | 10.8725 mL | |
| 10 mM | 0.5436 mL | 2.7181 mL | 5.4363 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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