| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg | |||
| Other Sizes |
| Targets |
IC50: 18.9 μM (HSV-1)[1]
HSV-1 (Herpes Simplex Virus type 1). |
|---|---|
| ln Vitro |
Soyasapogenol C exhibits negligible cytotoxicity and strong anti-HSV-1 action (IC50=18.9 μM) with a CC50 of 921 μM[1].
Soyasapogenol C shows potent anti-HSV-1 activity with an IC50 of 18.9 microM. Importantly, it exhibits negligible cytotoxicity, with a CC50 of 921 microM, indicating a high selectivity index. It modulates key signaling pathways such as NF-kappaB and MAPK, influencing apoptosis and cell proliferation. |
| ln Vivo |
Not available in the public domain. Its in vivo antiviral efficacy would typically be evaluated in mouse models of HSV-1 infection to assess its ability to reduce viral load and lesion formation.
|
| Enzyme Assay |
The anti-HSV-1 activity is assessed using a standard plaque reduction assay. Vero cells are infected with HSV-1 in the presence of varying concentrations of Soyasapogenol C. The number of plaques is counted, and the IC50 is determined from the dose-response curve.
|
| Cell Assay |
Cytotoxicity is assessed using a standard cell viability assay, such as MTT, on Vero cells. The CC50 (50% cytotoxic concentration) is determined, and the selectivity index is calculated as the ratio of CC50 to IC50.
|
| ADME/Pharmacokinetics |
Physicochemical properties: Molecular Weight = 440.7, Molecular Formula = C30H48O2. Purity: 97%. Storage: 4degC, protect from light; in solvent -80degC for 6 months, -20degC for 1 month (protect from light).
|
| References | |
| Additional Infomation |
Soyasapogenol C is a triterpenoid compound. It has been reported to exist in soybeans, alfalfa, and other organisms with relevant data. See also: Red clover flowers (partial).
Soyasapogenol C (CAS#: 595-14-2) is a bioactive natural product with potential therapeutic applications. Its potent and selective anti-HSV-1 activity, combined with its low cytotoxicity, makes it a promising lead compound for the development of new antiviral agents. It is also studied for its anti-inflammatory and anticancer properties. |
| Molecular Formula |
C30H48O2
|
|---|---|
| Molecular Weight |
440.70
|
| Exact Mass |
440.365
|
| CAS # |
595-14-2
|
| PubChem CID |
3083637
|
| Appearance |
White to off-white solid powder
|
| LogP |
6.917
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
32
|
| Complexity |
855
|
| Defined Atom Stereocenter Count |
9
|
| SMILES |
C[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H]([C@]5(C)CO)O)C)C)[C@@H]1CC(C=C2)(C)C)C
|
| InChi Key |
VNGUCOGHCJHFID-FLZFTVBESA-N
|
| InChi Code |
InChI=1S/C30H48O2/c1-25(2)14-15-26(3)16-17-29(6)20(21(26)18-25)8-9-23-27(4)12-11-24(32)28(5,19-31)22(27)10-13-30(23,29)7/h8,14-15,21-24,31-32H,9-13,16-19H2,1-7H3/t21-,22+,23+,24-,26+,27-,28+,29+,30+/m0/s1
|
| Chemical Name |
(3S,4S,4aR,6aR,6bS,8aS,12aR,14aR,14bR)-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,12,12a,14,14a-dodecahydropicen-3-ol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2691 mL | 11.3456 mL | 22.6912 mL | |
| 5 mM | 0.4538 mL | 2.2691 mL | 4.5382 mL | |
| 10 mM | 0.2269 mL | 1.1346 mL | 2.2691 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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