| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| 500mg | |||
| 1g | |||
| 5g | |||
| Other Sizes |
| Targets |
S-(3-Carboxypropyl)-L-cysteine does not have a well-defined pharmacological target. It is a thioether derivative of L-cysteine that serves as a research tool in studies of sulfur metabolism and thiol chemistry. It is utilized in investigations involving oxidative stress, enzymatic specificity, and biosynthetic pathway elucidation. It may also be involved in hydrogen sulfide signaling pathways.
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| ln Vitro |
In vitro, S-(3-Carboxypropyl)-L-cysteine is used as a research tool in studies of sulfur metabolism and thiol chemistry. It is utilized in investigations involving oxidative stress, enzymatic specificity, and biosynthetic pathway elucidation. The compound's structurally distinct side chain makes it valuable for studying cysteine metabolism and related biochemical processes. No specific pharmacological activity data are available.
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| ln Vivo |
In vivo, S-(3-Carboxypropyl)-L-cysteine has not been extensively characterized for pharmacological activity. As an amino acid derivative, it may be involved in metabolic pathways related to cysteine and sulfur metabolism. No specific in vivo efficacy or pharmacological data are available from publicly accessible sources.
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| Enzyme Assay |
In vitro enzyme assays for S-(3-Carboxypropyl)-L-cysteine typically involve studying its interactions with enzymes involved in sulfur metabolism, such as cystathionine γ-lyase (CSE) or other enzymes that metabolize cysteine derivatives. The compound can be used as a substrate or inhibitor in enzymatic assays to study enzyme specificity and kinetics. Product formation or substrate consumption is measured using HPLC, mass spectrometry, or colorimetric methods.
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| Cell Assay |
In vitro cell-based assays for S-(3-Carboxypropyl)-L-cysteine involve culturing cells and treating them with the compound to assess effects on sulfur metabolism, oxidative stress, or thiol homeostasis. Cells are treated with the compound at various concentrations, and markers of oxidative stress (e.g., ROS, glutathione levels) or metabolic intermediates are measured. Cell viability is assessed using MTT or CellTiter-Glo assays.
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| Animal Protocol |
In vivo animal studies for S-(3-Carboxypropyl)-L-cysteine have not been extensively reported. If conducted, such studies might involve animal models of oxidative stress or metabolic disorders, where the compound is administered and metabolic or biochemical endpoints are assessed. No specific data are available from publicly accessible sources.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of S-(3-Carboxypropyl)-L-cysteine have not been extensively characterized. As a small molecule with a molecular weight of 207.25 and a molecular formula of C7H13NO4S, it is expected to have good aqueous solubility. The compound is a white to off-white powder. Detailed PK parameters such as half-life, Cmax, and bioavailability are not available from publicly accessible sources.
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| Toxicity/Toxicokinetics |
The toxicity profile of S-(3-Carboxypropyl)-L-cysteine has not been systematically evaluated. As an amino acid derivative, it is expected to have low toxicity. Standard toxicology assessments would include acute and sub-chronic toxicity studies in rodents, with endpoints including clinical signs, body weight, clinical pathology, and histopathology. No specific toxicity data are available.
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| References |
1: Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019 Jul 12;294(28):11011-11022. doi: 10.1074/jbc.RA119.009047. Epub 2019 Jun 3. PubMed PMID: 31160338; PubMed Central PMCID: PMC6635441.
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| Additional Infomation |
S-(3-Carboxypropyl)-L-cysteine is a research compound and has not been approved for clinical use. It is a thioether derivative of L-cysteine featuring a carboxypropyl group bonded to the sulfur atom. This modification introduces unique chemical properties such as increased hydrophilicity. The compound serves as a valuable tool in studies of sulfur metabolism, thiol chemistry, oxidative stress, enzymatic specificity, and biosynthetic pathway elucidation.
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| Molecular Formula |
C7H13NO4S
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|---|---|
| Molecular Weight |
207.24
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| Exact Mass |
207.057
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| Elemental Analysis |
C, 40.57; H, 6.32; N, 6.76; O, 30.88; S, 15.47
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| CAS # |
30845-11-5
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| PubChem CID |
54439699
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| Appearance |
Solid powder
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| LogP |
0.696
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
13
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| Complexity |
185
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C(CC(=O)O)CSCC(C(=O)O)N
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| InChi Key |
WNFNRNDFHINZLV-YFKPBYRVSA-N
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| InChi Code |
InChI=1S/C7H13NO4S/c8-5(7(11)12)4-13-3-1-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)/t5-/m0/s1
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| Chemical Name |
(R)-4-[(2-Amino-2-carboxyethyl)thio]butanoic Acid
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| Synonyms |
S-(3-Carboxypropyl)-L-cysteine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8253 mL | 24.1266 mL | 48.2532 mL | |
| 5 mM | 0.9651 mL | 4.8253 mL | 9.6506 mL | |
| 10 mM | 0.4825 mL | 2.4127 mL | 4.8253 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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