| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
|
||
| 25mg |
|
||
| 100mg | |||
| 500mg | |||
| 1g | |||
| Other Sizes |
| Targets |
The molecular target of Perlolyrin has not been fully characterized. As a natural alkaloid isolated from Tribulus terrestris, Perlolyrin is believed to contribute to the pharmacological activities of the plant extract. Tribulus terrestris extracts have been reported to exhibit various biological activities, including enhancement of sexual function, anti-inflammatory effects, cardioprotective effects, and modulation of the immune system. The specific mechanisms underlying these effects are not fully understood and may involve multiple targets and pathways. Perlolyrin's role as a metabolite suggests that it may be involved in plant metabolism or may have biological activity in mammalian systems. Further research is needed to identify the specific molecular targets and mechanisms of action of Perlolyrin.
|
|---|---|
| ln Vitro |
In vitro activity of Perlolyrin has been studied as part of the characterization of Tribulus terrestris constituents. The compound is an alkaloid natural product that has been isolated and identified from plant material. Specific in vitro biological activities and potency data are limited in publicly available sources. As a natural product, Perlolyrin may exhibit various biological activities including antioxidant, anti-inflammatory, or other pharmacological effects. Further studies are needed to fully characterize the compound's in vitro activity profile. Perlolyrin is used as a reference compound for the chemical analysis of Tribulus terrestris extracts and for studying the pharmacology of its constituents.
|
| ln Vivo |
In vivo activity of Perlolyrin has not been extensively documented in publicly available sources. As a natural alkaloid isolated from Tribulus terrestris, the compound may contribute to the in vivo effects of plant extracts. Tribulus terrestris extracts have been studied in various animal models for their aphrodisiac, anti-inflammatory, cardioprotective, and other effects. However, specific in vivo studies with purified Perlolyrin have not been reported in publicly available literature. The compound is primarily used as a reference standard for analytical and research purposes rather than for in vivo efficacy studies.
|
| Enzyme Assay |
The isolation and characterization of Perlolyrin from plant material involves standard natural product chemistry techniques. Dried fruits of Tribulus terrestris are extracted with organic solvents (such as methanol or ethanol), and the crude extract is subjected to fractionation using chromatographic techniques including column chromatography, preparative TLC, or HPLC. Purified Perlolyrin is identified and characterized using spectroscopic methods including NMR, MS, and IR spectroscopy. The compound's identity is confirmed by comparison with published spectral data. Purity is assessed by HPLC or TLC.
|
| Cell Assay |
Cellular assays for Perlolyrin have not been extensively documented in publicly available sources. As a natural product isolated from Tribulus terrestris, the compound may be studied in cell-based assays to evaluate its biological activities. Potential cellular assays could include assessment of antioxidant activity (using ROS detection or cell protection assays), anti-inflammatory activity (measuring cytokine production or NF-κB activation), or other relevant endpoints. However, specific cellular assay protocols for Perlolyrin are not widely reported in the literature. The compound is primarily used as an analytical reference standard.
|
| Animal Protocol |
In vivo studies with Perlolyrin have not been extensively documented. As a natural product constituent of Tribulus terrestris, the compound may be studied in animal models to evaluate its pharmacokinetic properties or biological activities. However, specific in vivo experimental protocols for Perlolyrin are not widely reported in publicly available sources. The compound is primarily used as a reference standard for the analysis of Tribulus terrestris extracts and for natural product chemistry research.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of Perlolyrin (molecular weight 264.28, molecular formula C16H12N2O2) have not been extensively characterized. As a natural product alkaloid, the compound's absorption, distribution, metabolism, and excretion properties have not been detailed in publicly available sources. The compound is typically supplied as a solid for research use. Comprehensive PK parameters including oral bioavailability, half-life, and volume of distribution are not available.
|
| Toxicity/Toxicokinetics |
Perlolyrin is intended for research use only and is not approved for human therapeutic applications. Comprehensive toxicological evaluations have not been reported in publicly available sources. As a natural product constituent of Tribulus terrestris, the compound's safety profile has not been extensively characterized in isolation. Researchers should handle the compound with appropriate safety precautions for natural product research chemicals.
|
| References |
1: Shaaban M, Shaaban KA, Helmke E, Grün-Wollny I, Laatsch H. Isolation and Structural Elucidation of Nitrogenous Secondary vetabolites from Terrestrial and Marine Streptomyces spp. Nat Prod Commun. 2017 Mar;12(3):351-354. PMID: 30549883. 2: Fotso S, Maskey RP, Schröder D, Ferrer AS, Grün-Wollny I, Laatsch H. Furan oligomers and beta-carbolines from terrestrial streptomycetes. J Nat Prod. 2008 Sep;71(9):1630-3. doi: 10.1021/np800248s. Epub 2008 Aug 21. PMID: 18715034. 3: Li Y, Zhao M, Parkin KL. β-carboline derivatives and diphenols from soy sauce are in vitro quinone reductase (QR) inducers. J Agric Food Chem. 2011 Mar 23;59(6):2332-40. doi: 10.1021/jf104653n. Epub 2011 Feb 18. PMID: 21332190. 4: El-Bondkly AM, Abd-Alla HI, Shaaban M, Shaaban KA. The Electrospray Ionization - Mass Spectra of Erythromycin A Obtained from a Marine Streptomyces sp. Mutant. Indian J Pharm Sci. 2008 May-Jun;70(3):310-9. doi: 10.4103/0250-474X.42979. PMID: 20046738; PMCID: PMC2792501.
|
| Additional Infomation |
Perlolyrine is an organic molecular entity that functions as a metabolite. It has been reported to be found in Polygala tenuifolia, Codonopsis pilosula, and other organisms with relevant data.
Perlolyrin (Tribulusterine) is a natural alkaloid isolated from the dried fruits of Tribulus terrestris, a plant widely used in traditional medicine. Tribulus terrestris extracts have been reported to possess various pharmacological activities including aphrodisiac, anti-inflammatory, and cardioprotective effects. Perlolyrin is one of the alkaloid constituents of this plant and serves as a research tool for studying the chemistry and pharmacology of Tribulus terrestris. The compound has a molecular formula of C16H12N2O2 and a molecular weight of 264.28. Perlolyrin is available as a research-grade compound for natural product chemistry and pharmacological studies. The compound is also known by the synonym Tribulusterine. |
| Molecular Formula |
C16H12N2O2
|
|---|---|
| Molecular Weight |
264.28
|
| Exact Mass |
264.09
|
| Elemental Analysis |
C, 72.72; H, 4.58; N, 10.60; O, 12.11
|
| CAS # |
29700-20-7
|
| PubChem CID |
160179
|
| Appearance |
Typically exists as solid at room temperature
|
| Melting Point |
183 °C
|
| LogP |
3.468
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
20
|
| Complexity |
351
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1(C2OC(CO)=CC=2)C2NC3C(C=2C=CN=1)=CC=CC=3
|
| InChi Key |
KFUCYPGCMLPUMT-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H12N2O2/c19-9-10-5-6-14(20-10)16-15-12(7-8-17-16)11-3-1-2-4-13(11)18-15/h1-8,18-19H,9H2
|
| Chemical Name |
(5-(9H-pyrido[3,4-b]indol-1-yl)furan-2-yl)methanol
|
| Synonyms |
Tribulusterine; Perlolyrine; 29700-20-7; perlolyrin; Substance YS;
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7839 mL | 18.9193 mL | 37.8387 mL | |
| 5 mM | 0.7568 mL | 3.7839 mL | 7.5677 mL | |
| 10 mM | 0.3784 mL | 1.8919 mL | 3.7839 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
