| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| Other Sizes |
| Targets |
Palmitic acid-d31 itself does not have a traditional biological target; it is a stable isotope-labeled internal standard. The parent compound Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid-d31 is used to track and quantify palmitic acid in biological samples for metabolic and lipid studies.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
Palmitic acid-d31 does not exhibit direct in vitro biological activity as it is an analytical standard. However, the parent compound Palmitic acid is a common saturated fatty acid involved in lipid metabolism and cellular signaling. Palmitic acid-d31 is used as an internal standard to accurately measure palmitic acid concentrations in biological samples, facilitating research on lipid metabolism and fatty acid pathways. |
| ln Vivo |
Palmitic acid-d31 is not intended for in vivo administration as a therapeutic agent; it is used as an analytical standard. The in vivo activity of the parent compound Palmitic acid is associated with its role in lipid metabolism and energy storage. Palmitic acid-d31 is utilized in pharmacokinetic and metabolic studies to track the distribution, metabolism, and excretion of palmitic acid in biological systems.
|
| Enzyme Assay |
In vitro enzyme/receptor binding assays for Palmitic acid-d31 are not typically performed, as it is an analytical standard. Instead, the compound is used in analytical method development and validation. Quality control assays involve HPLC or LC-MS/MS to verify isotopic purity (≥98 atom % D) and chemical purity. The compound is tested for stability under various storage conditions. It appears as a solid and is soluble in organic solvents.
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| Cell Assay |
Palmitic acid-d31 itself is not tested in in vitro cellular assays for biological activity, as it is an analytical standard. Its utility is assessed by its performance as an internal standard in analytical workflows, including its ability to provide accurate quantification in GC-MS or LC-MS analyses. The compound is used in quality control applications for fatty acid analysis.
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| Animal Protocol |
In vivo animal studies for Palmitic acid-d31 are not conducted as therapeutic efficacy studies. Instead, the compound is administered to animals as a tracer in pharmacokinetic studies to quantify the parent compound palmitic acid in plasma, tissues, and excreta. These studies help determine the absorption, distribution, metabolism, and excretion (ADME) profile of palmitic acid in lipid metabolism research.
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| ADME/Pharmacokinetics |
Palmitic acid-d31 has a molecular formula of C16HD31O2 and a molecular weight of 287.59. It has a purity of ≥98% and an isotopic enrichment of ≥98 atom % D. It appears as a solid. The compound is stable under recommended storage conditions. It is intended for research use only and is not for human consumption.
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| Toxicity/Toxicokinetics |
The toxicity profile of Palmitic acid-d31 is not extensively characterized, as it is an analytical standard rather than a therapeutic agent. The parent compound Palmitic acid is a common dietary fatty acid that is generally recognized as safe. Palmitic acid-d31 is intended for research use only and is not approved for clinical use. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Palmitic acid-d31 is a C16 straight-chain saturated fatty acid in which aliphatic hydrogen atoms are replaced by deuterium atoms. It is a deuterated fatty acid, a long-chain fatty acid, and a straight-chain saturated fatty acid. Functionally, it is related to hexadecanoic acid.
Palmitic acid-d31 (CAS 39756-30-4) is a perdeuterated stable isotope-labeled analog of the 16-carbon saturated fatty acid, palmitic acid, wherein all 31 hydrogen atoms are replaced with deuterium. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. This highly deuterated compound is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS in metabolic and lipid research. It is intended for research use only and is not approved for clinical use. |
| Molecular Formula |
C16HD31O2
|
|---|---|
| Molecular Weight |
287.62
|
| Exact Mass |
256.24
|
| CAS # |
39756-30-4
|
| Related CAS # |
Palmitic acid;57-10-3;Palmitic acid sodium;408-35-5;Palmitic acid-d2;62689-96-7;Palmitic acid-15,15,16,16,16-d5;285979-77-3
|
| PubChem CID |
16212358
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| Appearance |
White to off-white solid powder
|
| Density |
0.9±0.1 g/cm3
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| Boiling Point |
340.6±5.0 °C at 760 mmHg
|
| Melting Point |
61-64ºC(lit.)
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| Flash Point |
154.1±12.5 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.454
|
| LogP |
7.15
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| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
18
|
| Complexity |
178
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)O
|
| InChi Key |
IPCSVZSSVZVIGE-SAQPIRCFSA-N
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| InChi Code |
InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/i1D3,2D2,3D2,4D2,5D2,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2
|
| Chemical Name |
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-hentriacontadeuteriohexadecanoic acid
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (347.68 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.69 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4768 mL | 17.3840 mL | 34.7681 mL | |
| 5 mM | 0.6954 mL | 3.4768 mL | 6.9536 mL | |
| 10 mM | 0.3477 mL | 1.7384 mL | 3.4768 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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